LF:ZLFA0621p Pharmacology I - lect.

ZLFA0621p Pharmacology I - lecture

Faculty of Medicine
spring 2019

Extent and Intensity

1/0/0. 0 credit(s). Type of Completion: -.

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Timetable

Wed 6. 3. to Wed 17. 4. Wed 16:00–17:40 B11/334; and Wed 27. 2. 17:00–18:40 B11/334

Prerequisites (in Czech)

ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

Dentistry (eng.) (programme LF, M-ZL)
Dentistry (programme LF, M-ZL)

Course objectives

At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.

Learning outcomes

Syllabus

LECTURES
Spring semester 2019
1^st week
Historical aspects of pharmacology. Pharmacology — definitions, terminology, subspecializations. The active substance, pharmacon - drug. Effective pharmacotherapy.
2^nd week
Mechanisms of drug action, non-specific, specific. Receptor and binding sites subtypes, autoreceptors, heteroreceptors, their function.
3^rd week
Basic principles of Pharmacokinetics. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration.
4^th week
Drug interactions. Assessment of the seriousness of drug interactions.
5^th week
Adverse drug effects. Physiological and pathological factors influencing drug effects. Influence of concomitant diseases on drug effect, polypragmasia.
6^th week
Specificities of pharmacotherapy in pediatric population.
7^th week
Specificities of pharmacotherapy in elderly.
8^th week
General principles of drug poisoning, specific antidotes and their mechanisms of action.

Literature

required literature

RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html

recommended literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
http://elportal.cz/publikace/kazuistiky-farmakologie
http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html

not specified

Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info

Teaching methods

According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.

Assessment methods

There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 15.

The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.

Enrolment Statistics (spring 2019, recent)
Permalink: https://is.muni.cz/course/med/spring2019/ZLFA0621p

LF:ZLFA0621p Pharmacology I - lect. - Course Information

ZLFA0621p Pharmacology I - lecture

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