aZLFA0621c Pharmacology I - practice

Faculty of Medicine
spring 2019
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
PharmDr. Adriána Papiež, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 27. 5. 7:00–12:30 A19/326, Tue 28. 5. 7:00–12:30 A19/326, Wed 29. 5. 7:00–12:30 A19/326, Thu 30. 5. 7:00–12:30 A19/326, Fri 31. 5. 7:00–12:30 A19/326
Prerequisites (in Czech)
aZLPA0521c Pathology I - practice && aZLPF0521c Pathophysiol.I - practice && aZLCP051c Clin. Introd. in Surgery-prac.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After completing of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Learning outcomes
After finishin the course the student will be able:
- to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations.
- to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Syllabus

  • Pharmacology - practical courses

    Dentistry

    Spring semester 2019

  • /1/
  • INTRODUCTION TO THE STUDY OF PHARMACOLOGY
  • Contents of the study of Pharmacology, contents and organization of theoretical and practical courses and lectures, required and recommended textbooks. The conditions for granting the credit. Pharmacology - definition, basic terminology, subspecializations, drug nomenclature. Introduction to the prescription terminology. Classification of drug preparations. Pharmacopoea, Pharmacopoea Bohemica.
  • INTRODUCTION TO THE PHARMACOKINETICS
  • Transport of drugs across biological barriers. Basic pharmacokinetic processes. Pharmacokinetic parameters. Pharmacokinetics of single and repeated intravascular and extravascular drug administration. Therapeutic drug monitoring (therapeutic monitoring of drug plasmatic concentrations).
  • /2/
  • GENERAL RULES OF THE DRUG PRESCRIPTION
  • Medical prescription and its essentials. Prescription of drugs. Legislation of drug prescription. Work with various handbooks and databases (SÚKL database, Pharmindex, AISLP etc.). Prescription and provisions of narcotic and psychotropic substances.
  • PRESCRIPTION OF READY MADE PREPARATIONS – practice. SOLID DRUG DOSAGE FORMS
  • Prescription of selected drug forms (solid drug dosage forms – powders, capsules, tablets, suppositories).
  • SOFT AND MELTING DRUG DOSAGE FORMS
  • Prescription of selected drug forms (soft and melting drug dosage forms – ointments, creams, pastes, gels and other preparations for application to the skin and mucous membranes).
  • FLUID DRUG DOSAGE FORMS
  • Prescription of selected drug forms (fluid drug dosage forms - solutions for rubbing, compresses and lavages, solutions and drops for oral administration).
  • SPECIAL PRESCRIPTION OF INDIVIDUALLY PREPARED DRUGS USED IN STOMATOLOGY (mucoadhesive pastes, solutions, suspensions, gels, ointments, pastes).
  • /3/
  • PHARMACOLOGY OF PERIPHERAL NERVOUS SYSTEM
  • Introduction. Terminology, neurotransmissions in peripheral nervous system, adrenergic and cholinergic receptors, agonists and antagonists. Functional importance and possibilities of pharmacological affection of sympathetic and parasympathetic system.
  • NORADRENERGIC (SYMPATHETIC) DRUGS
  • Introduction. Receptors of noradrenergic (sympathetic) system, pharmacology of drugs activating and blocking noradrenergic (sympathetic) system.
  • /4/
  • PRESCRIPTION TEST (PRESCRIPTION OF READY MADE PREPARATIONS AND LATIN TRANSLATIONS)
  • NORADRENERGIC (SYMPATHETIC) DRUGS
  • Completion. Receptors of noradrenergic (sympathetic) system, pharmacology of drugs activating and blocking noradrenergic (sympathetic) system.
  • CHOLINERGIC (PARASYMPATHETIC) DRUGS
  • Receptors of cholinergic (parasympathetic) system, pharmacology of drugs activating and blocking cholinergic (parasympathetic) system.
  • /5/
  • MULTIPLE CHOICE FINAL (CREDIT) TEST OF PHARMACOLOGY (MCHQ - topics lessons from days 1 to 4)
  • GLUCOCORTICOIDS
  • Receptors of noradrenergic (sympathetic) system, pharmacology of drugs activating and blocking noradrenergic (sympathetic) system.
  • CHOLINERGIC (PARASYMPATHETIC) DRUGS
  • Physiology and pathophysiology of adrenal cortex hormones. Natural and synthetic adrenocorticosteroids, steroid receptors, mechanism of action, pharmacological use and side effects. Examples of ready-made drug preparations.
  • H1 ANTIHISTAMINES, ANTIASTHMATICS
  • Classification and clinical use of H1 antihistamines. Pathophysiology of bronchial asthma, sites and mechanisms of action of antiasthma drugs. Prescription of antitussives, expectorants, antiasthmatics.
  • ANTIDIABETIC DRUGS
  • Therapy of type 1 and 2. DM. Insulines. Peroral antidiabetics. Examples of ready-made drug preparations.
  • CREDITS
Literature
    required literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010, 96 pp. ISSN 1801-6103. URL info
  • For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
    recommended literature
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
    not specified
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • ZELENKOVÁ, Olga and Alexandra ŠULCOVÁ. Speciální stomatologická receptura pro praktická cvičení z farmakologie (Special stomatological prescriptions for practicals in pharmacology). 2. přepracované vydání. Brno: Masarykova univerzita v Brně, 2000, 30 pp. ISBN 80-210-2433-X. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Český lékopis 2009. Praha: Grada, 2011, 1 DVD-ROM. ISBN 8594049240180. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • http://portal.med.muni.cz/clanek-652-behavioralni-metody-v-neuropsychofarmakologii.html ruda 2016
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • ŠULCOVÁ, Alexandra. Poznámky k přednáškám z farmakologie. 1. vyd. Brno: Masarykova univerzita, 1993, 97 s. ISBN 80-210-0640-4. info
Teaching methods
Practicals, the teaching process of include theoretical setting up as well as practical training of knowledge and skills stated in Syllabus. Included are also individual work with specific pharmacological softwares and homeworks on the selected topics, presented and discussed afterward in class.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 2 written tests: 1) on drug prescription + translation of selected prescription expressions into Latin (assessed individually by the teacher), 2) the multiple-choice test on knowledge of topics taught. More than half correctly answered questions (usually from 15) are required.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2018, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2019, recent)
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