ZLFA0621p Pharmacology I - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
1/0/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
PharmDr. Adéla Bártová (seminar tutor)
MVDr. Eva Dražanová, Ph.D. (seminar tutor)
PharmDr. Tomáš Hammer (seminar tutor)
PharmDr. Mária Hricková (seminar tutor)
PharmDr. Eva Klásková (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Mgr. Marta Vyoralová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 16. 2. 16:00–17:40 A19/231, Mon 7. 3. 14:00–15:40 C15/333, Mon 14. 3. 14:00–15:40 C15/333, Mon 21. 3. 14:00–15:40 C15/333, Mon 28. 3. 14:00–15:40 C15/333, Mon 4. 4. 14:00–15:40 C15/333, Mon 11. 4. 14:00–15:40 C15/333
Prerequisites (in Czech)
ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Learning outcomes
At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
Syllabus
  • LECTURES

  • Spring semester 2022

  • 1st lecture
  • Historical aspects of pharmacology. Pharmacology — definitions, terminology, subspecializations. The active substance, pharmacon - drug. Effective pharmacotherapy.
  • 2nd lecture
  • Mechanisms of drug action, non-specific, specific. Receptor and binding sites subtypes, autoreceptors, heteroreceptors, their function.
  • 3rd lecture
  • Basic principles of Pharmacokinetics. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration.
  • 4th lecture
  • Adverse drug effects. Drug interactions at different levels. Assessment of their seriousness.
  • 5th lecture
  • Physiological and pathological factors influencing drug effects. Influence of concomitant diseases on drug effect.
  • 6th lecture
  • Specificities of pharmacotherapy in elderly. Polypragmasia. Effective pharmacotherapy.
  • 7th lecture
  • General principles of poisoning management. Specific antidotes in poisoning therapy.
Literature
    required literature
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN and H. P. RANG. Rang and Dale's pharmacology. Ninth edition. Edinburgh: Elsevier, 2020, xvi, 789. ISBN 9780702074486. info
  • Studijní materiály v IS pod kódem předmětu
  • NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010, 96 pp. ISSN 1801-6103. URL info
  • http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html
  • For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
    recommended literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty MU
  • Farmakologie. Edited by Jan Švihovec - Jan Bultas - Pavel Anzenbacher - Jaroslav Chládek - J. 1. vydání. Praha: Grada Publishing, 2018, xix, 962. ISBN 9788024755588. info
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
    not specified
  • http://elportal.cz/publikace/kazuistiky-farmakologie
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
Teaching methods
According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.
Assessment methods
There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 15.
The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2022, recent)
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