EMEM0832p Embryology II

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
PharmDr. Zuzana Holubcová, Ph.D. (lecturer)
Drahomíra Kyjovská (assistant)
MUDr. Eva Mecová (assistant)
Guaranteed by
doc. MVDr. Aleš Hampl, CSc.
Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. to Mon 1. 4. Mon 14:30–16:10 F01B1/126, Mon 15. 4. to Fri 31. 5. Mon 14:30–16:10 F01B1/126; and Mon 8. 4. 14:00–15:40 A18/124
Prerequisites
EMEM0731p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is for students to thoroughly understand the molecular mechanisms involved in the interaction of germ cells and in preimplantation embryonic development.
Learning outcomes
Graduates of the course will: Have a comprehensive and thorough understanding of the molecular mechanisms of fertilization and the biology of preimplantation embryos. Be able to critically analyze and interpret scientific findings and assess their significance for clinical practice.
Syllabus
  • Preparation for fertilization, receptor interaction of gametes Molecular mechanisms of fertilization - release of MII arrest, completion of meiotic division, chromatin decondensation, formation and migration of pronuclei, centrosome inheritance Mechanisms blocking polyspermy Artificial activation of the oocyte, parthenogenesis Preimplantation development – cleavage division, compaction, blastulation Activation of the embryonic genome, genomic imprinting Metabolism and nutritional requirements of the embryo Totipotency and pluripotency, initial differentiation processes and cell line specification, transdifferentiation Influence of physical and chemical factors on the success of in vitro embryonic culture Disorders of embryonic development Genetic instability, causes of embryonic aneuploidy, mosaicism, correction mechanisms Embryonic stem cells Evaluation of embryo quality in the clinical laboratory Modern trends in experimental embryology and innovations in clinical practice
Literature
    recommended literature
  • Coward K., Wells D.: Textbook of Clinical Embryology, 1st ed., Cambridge 2013.
  • Trounson A, Gosden R, Eichenlaub-Ritter: Biology and Pathology of the Oocyte. 2nd ed., Cambridge 2013. Gardner DK, Sakkas D, Seli E, Wells D: Human gametes and preimplantation Embryos. 1st ed. New York 2013.
  • In vitro fertilization. Edited by Kay Elder - Brian Dale. 2nd ed. New York: Cambridge University Press, 2000, xii, 310 p. ISBN 0521778638. info
Teaching methods
lectures + excursion The condition for admission to the exam is participation in 1) lectures by external lecturers and 2) an excursion carried out during the semester
Assessment methods
oral exam
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/spring2024/EMEM0832p