VZB52 Genetics

Faculty of Education
Spring 2024
Extent and Intensity
1/1/0. 3 credit(s). Type of Completion: k (colloquium).
Teacher(s)
Mgr. et Mgr. Lenka Falk, Ph.D. (lecturer)
doc. MUDr. Petr Kachlík, Ph.D. (lecturer)
Guaranteed by
Mgr. et Mgr. Lenka Falk, Ph.D.
Department of Physical Education and Health Education – Faculty of Education
Contact Person: Andrea Špačková
Supplier department: Department of Physical Education and Health Education – Faculty of Education
Timetable of Seminar Groups
VZB52/KombiSem01: Fri 3. 5. 14:00–17:50 učebna 27, Fri 10. 5. 15:00–18:50 učebna 21, L. Falk
VZB52/PrezSem01: Mon 18:00–19:50 učebna 32, L. Falk
Prerequisites (in Czech)
VZB11 Human Biology and the Foundations of a Health Education
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
On the basis of the knowledge acquired the students will understand the importance of inherited qualities of an individual, describe the human genome, the principle of mutations, causes and consequences of their occurrence, basic genetic diseases, and the causes of lifestyle diseases in a broader context.
Learning outcomes
Upon completion of the course the students will: Be able to clearly explain the basic genetic concepts, Mendel’s laws and principles of heredity, Understand and be able to explain examples of monohybridism and dihybridism, propose suitable teaching examples for elementary schools, Understand the molecular principle of heredity, function of nucleic acids, and gene expression, Be able to see the human genome in the context of the creation, development and health of a human being.
Syllabus
  • 1. Basic genetic concepts and principles: heredity, variability, gene, allele and their relations, genotype, phenotype; 2. Basic genetic principles: Mendel’s phenotype laws. Monohybridism, dihybridism; 3. Chromosomal principle of heredity. Structure and significance of chromosomes. Human karyotype; 4. Cell cycle, mitosis, meiosis. Gametogenesis. Cell cycle regulation; 5. Molecular principle of heredity. Structure and function of nucleic acids. Genome; 6. DNA replication. Gene expression – transcription, translation. Genetic code. Protein synthesis. Human genome; 7. Monogenic inheritance in humans. Mutation. Genetic disorders in humans – gene-based. Autosomal dominant, autosomal recessive disorders; 8. Deviations from Mendelian segregation ratios. Gene linkage. Gene interaction. Gonosomal inheritance. Extranuclear inheritance; 9. Genetic disorders in humans – genome mutations. Aneuploidy in humans; 10. Genetic disorders in humans – chromosomal aberrations. Mutagens; 11. Inheritance of quantitative traits. Polygenous inheritance in humans. Multifactorial and complex traits in humans. Cancer – genetic disease; 12. Genetic prevention. Prenatal diagnosis. Assisted reproduction, pre-implantation diagnosis. Content of seminars: 1. Basic genetic principles, dominance and recessiveness; 2. Mendel’s crossing peas experiments; 3. Principle of segregation – training on specific examples of non-pathological traits in humans; 4. Monohybridism – training on specific examples of pathological traits in humans; 5. Inheritance of blood groups in humans, AB0 system, Rh-factor, molecular and biochemical principles, Bombay phenotype; 6. Blood groups – examples; 7. Principle of combination – training on specific examples of vegetable and animal organisms; 8. Dihybridism – training on specific examples of hereditary traits in humans; 9. Principles of segregation and combination in the context of cell division, mitosis, meiosis, chromatin replication and division; 10. Molecular principles – replication, transcription, translation – examples; 11. - 12. Bioethics in genetics – discussion on current issues (GMO, assisted reproduction, genetic research, etc.)
Literature
    required literature
  • ŠMARDA, Jan. Genetika : pro gymnázia. 1. vyd. Praha: Fortuna, 2003, 143 s. ISBN 8071688517. info
    recommended literature
  • NUSSBAUM, Robert L., Roderick R. MCINNES, Huntington F. WILLARD, James THOMPSON a Margaret Wilson THOMPSON. Klinická genetika: Thompson &Thompson : 6. vyd.Translated by Petr Goetz. Vyd. 1. Praha: Triton, 2004. 426, lix. ISBN 8072544756.
  • KŘEČEK, Jiří. Jedinec: Gen – prostředí – vývoj. 1. vyd. Praha: Academia, 2007. 232 s. ISBN 978-80-200-1490-0.
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Principles of genetics [Snustad, Simmons, 2000]. 2nd ed. New York: John Wiley & Sons, 2000, xviii, 876. ISBN 0-471-29800-X. info
Teaching methods
Theoretical preparation – lectures; Seminar - exercise, discussion
Assessment methods
The condition for admission to the colloquium is the successful completion of a written test on genetic examples (the minimum threshold for successful completion is 60%). The colloquium takes place as an oral examination of the discussed topics. The student draws two questions, a positive assessment of both questions is a necessary condition for successful completion.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 8 hodin.
The course is also listed under the following terms Spring 2023, Spring 2025.
  • Enrolment Statistics (recent)
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