F1FA1_15 Pharmaceutical Analysis in Industry

Faculty of Pharmacy
Spring 2021
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. Ing. Jiří Dohnal, CSc., MBA (lecturer)
Guaranteed by
doc. Ing. Jiří Dohnal, CSc., MBA
Department of Chemical Drugs – Departments – Faculty of Pharmacy
Timetable
Wed 19. 5. 9:00–12:00 45-135, 13:00–16:45 45-135, Thu 20. 5. 9:00–12:00 45-135
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 36 student(s).
Current registration and enrolment status: enrolled: 0/36, only registered: 0/36
fields of study / plans the course is directly associated with
Course objectives
Students will acquire knowledge about modern methods of the industrial pharmaceutical analysis, currently used either, in the pharmaceutical research and development, and in quality control of active pharmaceutical ingredients and finished dosage forms - "Life Cycle Management", or in analysis of starting material, intermediates and excipients. The accent will be put on methods and techniques of the solid state analysis, the structure analysis, and on the analysis of chiral compounds.
Learning outcomes
After completing the course, the student will be able to: - choose the optimal analytical method and analytical techniques for the given purpose from the areas - spectral methods (near and middle infrared spectroscopy in DRIFT or ATR arrangement, SS NMR, etc.); - diffraction methods (powder X-ray diffraction, laser diffraction, dynamic light scattering, Raman scattering); - thermal methods (DSC, TGA, TSC); - microscopic methods (optical microscopy and image analysis, electron microscopy) - and surface study methods (porosimetry, IGC and DVS). - correctly interpret the results obtained in this way and draw appropriate conclusions from them
Syllabus
  • Students with a deeper interest in industrial applications will be acquainted with the tasks of industrial analysis in all phases of the so-called "life cycle management". They will get acquainted with new approaches and methods of pharmaceutical analysis, eg with the principles of process analytical technology (PAT). Individual topics will be lectured by experts with many years of experience in the field and the explanation will be supplemented by illustrative examples from practice. Thematically, the block of lectures will be divided into a part dealing with structural analysis, analysis of optically active compounds and especially solid phase analysis.
Literature
    required literature
  • Jiří DOHNAL a Josef JAMPÍLEK a Vladimír KRÁL a Anna ŘEZÁČOVÁ. Moderní přístupy k farmaceutické analýze. Veterinární a farmaceutická univerzita Brno, 2010. ISBN 978-80-7305-095-5. info
    recommended literature
  • DOHNAL, Jiří a BRUSOVÁ, Hana a GRAFNETTEROVÁ, Taťjana a GRÜNWALD. . Moderní přístupy k farmaceutické analýze: 3. Farmaceutická analýza v pevné fázi. Veterinární a farmaceutická univerzita Brno, 2009. ISBN 978-80-7305-075-7. info
  • DOHNAL, Jiří a GRAFNETTEROVÁ, Taťjana a GRÜNWALDOVÁ, Veronika a. Moderní přístupy k farmaceutické analýze: 1. Analýza chirálních léčiv. Veterinární a farmaceutická univerzita Brno, 2009. ISBN 978-80-7305-051-1. info
  • DOHNAL, Jiří a GRAFNETTEROVÁ, Taťjana a GRÜNWALDOVÁ, Veronika a. Moderní přístupy k farmaceutické analýze: 2. Strukturní analýza léčiv. Veterinární a farmaceutická univerzita Brno, 2009. ISBN 978-80-7305-058-0. info
    not specified
  • A. Zakrzewski, M. Zakrzewski,. Solid State Characterization of Pharmaceuticals. Ed. Assa Inc., Danbury, 2006. info
Teaching methods
Lectures and discussions led mainly by experts from practice and from other universities in two blocks. Study of designated literature.
Assessment methods
Written exam
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
Min. 80% attendance at lectures and passing a written exam.
The course is also listed under the following terms Spring 2020.
  • Enrolment Statistics (recent)
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