F1OB1_14 Biology

Faculty of Pharmacy
Autumn 2024
Extent and Intensity
2/2/0. 5 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
MVDr. Jana Hložková, Ph.D. (lecturer)
doc. RNDr. Jan Hošek, Ph.D. (lecturer)
Mgr. Petra Herczogová (seminar tutor)
PharmDr. Dominika Kos, Ph.D. (seminar tutor)
Ing. Marcela Nejezchlebová (seminar tutor)
Mgr. Bc. Daniela Nykodýmová (seminar tutor)
Mgr. Ondřej Smištík (seminar tutor)
Guaranteed by
doc. RNDr. Jan Hošek, Ph.D.
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Supplier department: Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy (50,00 %), Department of Molecular Pharmacy – Departments – Faculty of Pharmacy (50,00 %)
Timetable
Mon 11:50–13:30 44-056, except Mon 14. 10.
  • Timetable of Seminar Groups:
F1OB1_14/01: each odd Monday 8:00–11:20 45-229, except Mon 4. 11. ; and Mon 4. 11. 8:00–11:20 44-016, P. Herczogová, D. Kos
F1OB1_14/02: each even Monday 8:00–11:20 45-229, except Mon 11. 11. ; and Mon 11. 11. 8:00–11:20 44-016, P. Herczogová, D. Kos
F1OB1_14/03: each odd Wednesday 14:00–17:20 45-229, except Wed 6. 11. ; and Wed 6. 11. 14:00–17:20 44-037, D. Kos, O. Smištík
F1OB1_14/04: each even Wednesday 14:00–17:20 45-229, except Wed 13. 11. ; and Wed 13. 11. 14:00–17:20 44-037, D. Kos, O. Smištík
F1OB1_14/05: each odd Thursday 7:00–10:20 45-229, except Thu 7. 11. ; and Thu 7. 11. 7:00–10:20 44-037, D. Kos, O. Smištík
F1OB1_14/06: each even Thursday 7:00–10:20 45-229, except Thu 14. 11. ; and Thu 14. 11. 7:00–10:20 44-037, D. Kos, O. Smištík
F1OB1_14/07: each odd Thursday 10:30–13:50 45-229, except Thu 7. 11. ; and Thu 7. 11. 10:30–13:50 44-037, D. Kos, D. Nykodýmová
F1OB1_14/08: each even Thursday 10:30–13:50 45-229, except Thu 14. 11. ; and Thu 14. 11. 10:30–13:50 44-037, D. Kos, D. Nykodýmová
F1OB1_14/09: each odd Thursday 14:00–17:20 45-229, except Thu 7. 11. ; and Thu 7. 11. 14:00–17:20 44-037, M. Nejezchlebová, D. Nykodýmová
Prerequisites
FAKULTA(FaF) || OBOR(MUSFaF)
Basic knowledge of biology, biochemistry and physics are required
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the study is to expand secondary school knowledge of biology so that students gain the necessary basis in terms of content and conceptual area of these disciplines, on the basis of which they could continue to study applied biological disciplines taught at the Faculty of Pharmacy. The study focuses on general, molecular and cellular aspects of biology, evolutionary biology and the basics of genetics. Due to the existence of the compulsory subject Molecular Biology in the 2nd year, this topic is not dealt with more broadly in the subject.
Learning outcomes
Students will gain extended knowledge of basic topics of general and cell biology. Emphasis is placed on the terminology of individual topics, which will allow you to orient and build on them in other related disciplines. The topic of the last lecture opens to students the opportunity to gain insight into the use of biological disciplines in practice. The aim of practical training is to acquire basic manual skills in microscopy and work with biological material.
Syllabus
  • Biology introduction to the subject, definition of the field, history, fields of biology, taxonomy, cell types Possibilities of imaging and imaging techniques in biology Membranes membrane structure (general features + viruses, prokaryotes, eukaryotes), transport across membranes diffusion, osmosis, transport proteins, ion channels and membrane potential, clinically important membranes Organelles, ER, GA, endosomes, lysosomes, peroxisomes, mechanisms of protein transfer into organelles, clinically important organelopathy General principles of intercellular communication in unicellular and multicellular organisms, signaling molecules, receptors associated with ion channels, G-proteins, enzymes, diseases of intercellular communication disorders Cell division - cell cycle (G1, S, G2, M), mitosis (prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis), meiosis, cell cycle regulation Reproduction of organisms asexual reproduction (binary division, gemiparia, fisiparia, vegetative reproduction), sexual reproduction (spermiogenesis, oogenesis, fertilization), gametopathy Introduction to genetics gene, genome, genotype, phenotype, Mendelian genetics, non-Mendelian genetics, epigenetics, transcription, translation, prokaryotic genome, eukaryotic genome, genetic diagnostic tests in medicine (present history) Biology of the immune system (IS) - phylo and ontogenesis of IS, nonspecific and specific immunity, antigen, antibody, opsonization, MHC system, medically important immune disorders, transplant immunity, Interactions of living systems symbiosis, commensalism, infections (prions, viruses, bacteria, parasites) and the environment (ecotoxicology, environmental stress, GMO) Current topics in biomedical fields Credit procedure Practical excercises I. Microscopic technique 1. Work safety. 2. Organization of teaching, keeping protocols, conditions for granting credits 3. Working with a light microscope 4. Prokaryotic and eukaryotic cell structure. 5. Plant and animal cell structure. II. Prokaryota and protozoa 1. Prokaryota 2. Bacterial smear, Gram staining 3.Sacharomyces smear, staining. 4. Protozoa hay infusion, native preparation 5. Types of movements ciliary, amoeboid, flagellar 6. Staining and morphology of lactic acid bacteria, fixed preparation III. Mitosis 1. Preparation of mitotic preparation, staining 2. Mitotic index 3. Chromosomes of karyotype assembly IV. Meiosis 1. Spermatogenesis 2.Histology of seed-forming epithelium 3. Sperm morphology species differences 4. Oogenesis 5. Ovarian histology 6. Sex chromosomes 7. Detection of Bar's body, preparation of the specimen, staining V. Body structure of mammals 1. Anatomical body structure of a rodent autopsy, video 2. Histological structure of tissues and organs VI. Credit procedure 1. Substitute exercises. 2. Checking protocols. 3. Granting of credits.Biology introduction to the subject, definition of the field, history, fields of biology, taxonomy, cell types Possibilities of imaging and imaging techniques in biology Membranes membrane structure (general features + viruses, prokaryotes, eukaryotes), transport across membranes diffusion, osmosis, transport proteins, ion channels and membrane potential, clinically important membranes Organelles, ER, GA, endosomes, lysosomes, peroxisomes, mechanisms of protein transfer into organelles, clinically important organelopathy General principles of intercellular communication in unicellular and multicellular organisms, signaling molecules, receptors associated with ion channels, G-proteins, enzymes, diseases of intercellular communication disorders Cell division - cell cycle (G1, S, G2, M), mitosis (prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis), meiosis, cell cycle regulation Reproduction of organisms asexual reproduction (binary division, gemiparia, fisiparia, vegetative reproduction), sexual reproduction (spermiogenesis, oogenesis, fertilization), gametopathy Introduction to genetics gene, genome, genotype, phenotype, Mendelian genetics, non-Mendelian genetics, epigenetics, transcription, translation, prokaryotic genome, eukaryotic genome, genetic diagnostic tests in medicine (present history) Biology of the immune system (IS) - phylo and ontogenesis of IS, nonspecific and specific immunity, antigen, antibody, opsonization, MHC system, medically important immune disorders, transplant immunity, Interactions of living systems symbiosis, commensalism, infections (prions, viruses, bacteria, parasites) and the environment (ecotoxicology, environmental stress, GMO) Current topics in biomedical fields Credit granting Practical excercises I. Microscopic technique 1. Work safety. 2. Organization of teaching, keeping protocols, conditions for granting credits 3. Working with a light microscope 4. Prokaryotic and eukaryotic cell structure. 5. Plant and animal cell structure. II. Prokaryota and protozoa 1. Prokaryota 2. Bacterial smear, Gram staining 3.Sacharomyces smear, staining. 4. Protozoa hay infusion, native preparation 5. Types of movements ciliary, amoeboid, flagellar 6. Staining and morphology of lactic acid bacteria, fixed preparation III. Mitosis 1. Preparation of mitotic preparation, staining 2. Mitotic index 3. Chromosomes of karyotype assembly IV. Meiosis 1. Spermatogenesis 2.Histology of seed-forming epithelium 3. Sperm morphology species differences 4. Oogenesis 5. Ovarian histology 6. Sex chromosomes 7. Detection of Bar's body, preparation of the specimen, staining V. Body structure of mammals 1. Anatomical body structure of a rodent autopsy, video 2. Histological structure of tissues and organs VI. Credit procedure 1. Substitute exercises. 2. Checking protocols. 3. Granting of credits.
Literature
    recommended literature
  • Otová B. a kol. Lékařská biologie a genetika I-III. Praha, 2016. URL info
  • Otová B.,Mihalová R. Základy biologie a genetiky člověka. Praha, 2014. ISBN 978-80-246-2109-8. info
  • Gartner LP, Hiatt JL. Cell biology and histology 7th. London, 2011. ISBN 978-1-4511-8951-3. info
  • Jelínek Jan. Biologie a fyziologie člověka a úvod do studia obecné genetiky. Olomouc, 2003. ISBN 80-7182-138-1. info
  • Rozsypal S. a kol. Nový přehled biologie. Praha, 2003. ISBN 8071832685. info
Teaching methods
Lectures Discussion, Consultation Demonstration Practical laboratory activities
Assessment methods
Full participation in exercises is obligatory.Submission of all protocols is required. This subject will be terminated by written test. In the case of failure the test students complete the subject by oral examination.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
Complete practical training. Students are required to process protocols. Ending the course: credit and test.
Activity Difficulty [h]
Domácí příprava na výuku 50
Příprava na zkoušku 100
Summary 150
The course is also listed under the following terms Autumn 2020, Autumn 2021, Autumn 2022, Autumn 2023.
  • Enrolment Statistics (recent)
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