FAFM1_14 Pharmacogenomics

Faculty of Pharmacy
Autumn 2024

The course is not taught in Autumn 2024

Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (lecturer)
Guaranteed by
PharmDr. Mgr. Alžběta Kružicová, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Pharmacogenomics deals with the study of genetic aspects of drug response variability. In this subject the students have chance to learn basic genetic factors which determine both drug effectiveness and side effects of this drug.
Learning outcomes
At the end of the course, the student will be able to identify and summarize important genetic factors that affect the pharmacokinetics and pharmacodynamics of drugs. Will be able to interpret clinically significant polymorphisms and their effect on pharmacotherapy. Furthermore, the student will be able to describe and compare genetic examinations that are performed within the individualization of pharmacotherapy.
Syllabus
  • 1. Introduction to the study of pharmacogenomics. Overview of the subject, basic terms
    2. Basics of human genetics/genomics
    3. Genetics and human diseases
    4. Gene polymorphism, its clinical relevance
    5. Pharmacogenetics and Pharmacokinetics I
    6. Pharmacogenetics and Pharmacokinetics II
    7. Pharmacogenetics and Pharmacodynamics I
    8. Pharmacogenetics and Pharmacodynamics II
    9. Pharmacogenetics and Pharmacodynamics III
    10. Modern methods in pharmacogenomics. Methods for determination of gene polymorphisms
    11. Bioinformatics
    12. Consultation
    13. Exam
Literature
    recommended literature
  • Strachan a kol. Human Molecular Genetics 3. ISBN 0-8153-4184-9. info
  • Pharmacogenomics : a primer for clinicians. Edited by Jerika T. Lam - Mary A. Gutierrez - Samit Shah. New York: McGraw Hill Medical, 2021, xii, 173. ISBN 9781260457100. info
  • Wilson and Walker's principles and techniques of biochemistry and molecular biology. Edited by Keith Wilson - John M. Walker - Andreas Hofmann - Samuel Clokie. Eighth edition. Cambridge: Cambridge University Press, 2018, xxx, 929. ISBN 9781316614761. info
Teaching methods
Lectures
Assessment methods
The final assessment is a written exam (the test consists of 25 questions, 60% of correct answers is needed to pass). No homework is required during the semester. There is no obligation to attend classes.
Náhradní absolvování
It is not possible to take the course in a substitute form.
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
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