FAGE1_16 Applied Genetics

Faculty of Pharmacy
Spring 2020
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Guaranteed by
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Theretical principles and practical applications of genetics in pharmaceutical sciences are thaugt. Special attention is paid to the use of genomics, proteomics and bioinformatics for new drug targeting and development, to genes causing human diseases and/or influencing the course of diseases, to genetics of pathogens and of the host/pathogen interactions, to genetic variation to drugs and to the use of molelecular techniques for diagnostics and for production of drugs and vaccines. Basic information on therapeutic cloning, xenotransplantations and genetics of laboratory animals is provided as well. External experts in specific areas are invited as speakers covering specific topics.
Learning outcomes
Basic knowledge forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics.
Syllabus
  • 1. Genetics and its place in contemporary biomedicine. New medicine and its importance for drug development and treatment. Genomics and its application.
    2. Genomics comparative, structural and functional. Principles, methods and practical use in pharmacies: pharmacogenomics.
    3. Fundamentals of genetics: gene identification, genetics of qualitative and complex features, genetic methods.
    4. The importance of genetic polymorphism. Pharmacogenetics: variability in response to therapy and drugs.
    5. Mutation, consequences of mutations. Mutagenic factors of the external environment, genotoxicity of chemicals with a focus on pharmaceuticals. Relationship between mutagenesis, teratogenesis and carcinogenesis.
    6. Genes Affecting Health Status I. Hereditary Diseases and Gene Therapy Possibilities.
    7. Genes Affecting Health Condition II. Genetic resistance to disease and its relationship to therapy.
    8. Genetics of health condition III Genetics of immune response and its importance in therapy.
    9. Genes Affecting Health Condition IV. Genetics of tumor diseases and practical use in therapy.
    10. Biological and genetic principles of chemotherapy. Antibioresistence and "multi-drug" resistance.
    11. Use of molecular techniques to produce new types of drugs. Principles of gene manipulation.
    12. Use of molecular techniques to produce vaccines. Types of vaccines.
    13. Genetics of laboratory animals. Types of strains and their use in pharmacies.
    14. New Trends in Genetics and Their Relationship to Pharmacy: Genetically Modified Organisms, Cloning, Xenotransplantation.
Literature
    recommended literature
  • Alberts et al. Essential cell biology. Garland Science, Taylor and Francis Group. ISBN 0-8153-3481-8. info
  • Alberts et al. Základy buněčné biologie, Úvod do molekulární biologie buňky. Espero Publishing, 1998. info
Language of instruction
English
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Teacher's information
Discipline does not practice, participation in the lectures is optional, the only requirement is the knowledge of the oral exam in the syllabus.
  • Enrolment Statistics (recent)
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