FASB1_16 Structural Biology and Proteomics

Faculty of Pharmacy
Spring 2020
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
RNDr. Jiří Jelínek, Ph.D. (lecturer)
Guaranteed by
RNDr. Jiří Jelínek, Ph.D.
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
Sequencing of human genome significantly extended scale for development
of new drugs. A structure-genomics has been created to help to determine
function of individual genes by high-throughput protein crystallography.
Experimentally determined structures of proteins and nucleic acids and
their complexes with inhibitors, substrates and drugs become the basis
for rational drug design. Big pharmaceutic corporations formed large and
expensive laboratories of structure biology. For this reason it is
necessary to introduce these progressive methods into pedagogic curriculum.
Syllabus
  • Lectures
    1. Structure of nucleic acids.
    2. General structure of proteins.
    3. Structure and function of cell organelles and compartments.
    4. Structure and function of selected cellular receptors.
    5. Structure and function of basic cytokines.
    6. Structure and function of immunoglobulins
    7. Methods of structure analysis
Literature
    recommended literature
  • Alberts et al. Essential cell biology. Garland Science, Taylor and Francis Group. ISBN 0-8153-3481-8. info
Language of instruction
English
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2020/FASB1_16