F1IA1_13 Instrumental Analytical Methods in Pharmaceutical Technology

Faculty of Pharmacy
Autumn 2020
Extent and Intensity
1/1/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
Mgr. Sylvie Pavloková, Ph.D. (lecturer)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
Mgr. Sylvie Pavloková, Ph.D. (seminar tutor)
Guaranteed by
doc. Mgr. Jan Muselík, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Wed 12:00–12:45 18-122
  • Timetable of Seminar Groups:
F1IA1_13/01: Wed 12:45–13:30 18-122
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 15 student(s).
Current registration and enrolment status: enrolled: 0/15, only registered: 0/15
fields of study / plans the course is directly associated with
Course objectives
The subject named "Instrumental analytical methods in the pharmaceutical technology" is dealing with modern instrumental methods useful in the field of the pharmaceutical technology, development and industry. The main aim of this subject is to create a comprehensive overview of methods used for the evaluation, analysis and quality control of pharmaceutical dosage forms. Main topics: Near and middle infrared spectroscopy, dissolution tests and drug content analysis (UV/VIS spectrophotometry, HPLC), light and electron microscopy, laser diffraction analysis, X-ray diffraction analysis, thermal analysis. The theoretical principles of selected methods are discussed and their practical applications are demonstrated.
Learning outcomes
After completing the course, the student will be able to: - summarize the main methods used in the analysis of solid dosage forms; - understand the theoretical basis of these methods; - describe the main applications of these methods in pharmaceutical research and industry.
Syllabus
  • 1 Middle and near infrared spectroscopy, principles, instrumentation, measurement techniques.
    Lecturer: doc. Mgr. Jan Muselík, Ph.D.
    2 Applications of infrared spectroscopy, evaluation of spectra
    Lecturer: doc. Mgr. Jan Muselík, Ph.D.
    3 Dissolution test, methods of determination of active compound content (UV/VIS spectrophotometry).
    Lecturer: doc. Mgr. Jan Muselík, Ph.D.
    4 Methods of determination of active compound content (HPLC).
    Lecturer: doc. Mgr. Jan Muselík, Ph.D
    5 Light microscopy.
    Lecturer: Mgr. Sylvie Pavloková, Ph.D.
    6 Scanning, transmission and environmental electron microscopy.
    Lecturer: Mgr. Sylvie Pavloková, Ph.D.
    7 Scanning probe microscopy.
    Lecturer: Mgr. Sylvie Pavloková, Ph.D.
    8 Methods of particle size determination (light microscopy, sedimentation analysis, sieve analysis, Coulter counter).
    Lecturer: Mgr. Sylvie Pavloková, Ph.D.
    9 Methods of particle size determination - laser diffraction
    Lecturer: Mgr. Sylvie Pavloková, Ph.D.
    10 X-ray analysis, instrumentation and applications in pharmaceutical technology.
    Lecturer: doc. Mgr. Jan Muselík, Ph.D.
    11 Methods of thermal analysis (differential thermal analysis - DTA, thermogravimetry - TGA).
    Lecturer: doc. Mgr. Jan Muselík, Ph.D.
    12 Methods of thermal analysis (differential scanning calorimetry - DSC).
    Lecturer: doc. Mgr. Jan Muselík, Ph.D.
    13 Tutorial giving

    SYLABUS OF LABORATORY PRACTICE
    1.-3. FT-NIR (analysis of model samples, evaluation of spectra by chemometric methods).
    4.-6. Optimization of chromatographic conditions, dissolution test of dosage form, chromatographic determination of active compound content.
    7.-8. Determination of particle size (analysis of model sample, e.g. pellets, microparticles, powders, suspenions).
    9. Evaluation of DSC, TGA a XRPD spectra. Calculations.
    10. Evaluation of effects of processing factors on dissolution profile.
    11.-13. Excursion to the laboratory of scanning electron microscopy.
Literature
    required literature
  • Muselík J. Vybrané instrumentální metody ve farmaceutické technologii. Brno, 2012. ISBN 978-80-7305-640-7. info
Teaching methods
lectures, laboratory practice
Assessment methods
Written test
Language of instruction
Czech
Further Comments
The course can also be completed outside the examination period.
The course is also listed under the following terms Autumn 2021, Autumn 2023.
  • Enrolment Statistics (Autumn 2020, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2020/F1IA1_13