F1AI1_15 Analytical Chemistry I

Faculty of Pharmacy
Autumn 2021
Extent and Intensity
2/3/0. 4 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. RNDr. Bc. Jiří Pazourek, Ph.D. (lecturer)
doc. RNDr. Bc. Jiří Pazourek, Ph.D. (seminar tutor)
Ing. Klára Odehnalová, Ph.D. (seminar tutor)
PharmDr. Tereza Padrtová, Ph.D. (seminar tutor)
Mgr. Hana Pížová, Ph.D. (seminar tutor)
Mgr. Anna Ruprechtová (seminar tutor)
Mgr. David Švestka (seminar tutor)
Bc. Gabriela Jelínková (assistant)
Mgr. Tomáš Crha (seminar tutor)
Mgr. Michaela Kuchynka, Ph.D. (seminar tutor)
Guaranteed by
doc. RNDr. Bc. Jiří Pazourek, Ph.D.
Department of Chemical Drugs – Departments – Faculty of Pharmacy
Supplier department: Department of Chemical Drugs – Departments – Faculty of Pharmacy
Timetable
Mon 9:55–11:35 45-135
  • Timetable of Seminar Groups:
F1AI1_15/01: each odd Wednesday 7:30–12:30 44-339, T. Crha, J. Pazourek
F1AI1_15/02: each even Wednesday 7:30–12:30 44-339, M. Kuchynka, J. Pazourek
F1AI1_15/03: each odd Wednesday 13:00–18:00 44-339, H. Pížová, D. Švestka
F1AI1_15/04: each even Wednesday 13:00–18:00 44-339, T. Crha, M. Kuchynka
F1AI1_15/05: each odd Thursday 7:30–12:30 44-339, T. Crha, T. Padrtová
F1AI1_15/06: each even Thursday 7:30–12:30 44-339, T. Padrtová
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 160 student(s).
Current registration and enrolment status: enrolled: 93/160, only registered: 0/160
fields of study / plans the course is directly associated with
Course objectives
Objectives: To provide the theoretical and practical knowledge for qualitatively performing chemical and instrumental analysis of inorganic and organic substances including pharmaceuticals, emphasizing the importance of methods e.g. in drug analysis and in studying structural and physico-chemical properties of substances related to their biological effect. Emphasis is placed on shaping the logical thought processes of a pharmacist important for his future professional use. Practical exercises are required to master working habits and students' independent approach to solving analytical problems.
Learning outcomes
After completing the course, the student will be able to: - understand the meaning and principles of classical and modern analytical chemistry - have an overview of methods of qualitative analytical chemistry - practically perform basic laboratory tests of qualitative analytical chemistry
Syllabus
  • Content of the lectures 1.-2. Analytical chemistry. The goal and basic terms of the science, methods. Analytical reactions. Protolytic, redox, precipitation and complexation reactions. Buffers. 3.-6. Qualitative analysis of inorganic compounds. Group reactions of cations and anions. Selective and specific reactions of common ions 7.-8. Qualitative analysis of organic compounds - Identification of organic compounds. Elemental analysis. Classical confirmations and identification of functional groups. Preliminary test. Determination of basic physical constants. Classes of solubility. 9. Qualitative analysis of organic compounds. Instrumental methods of structure analysis: UV-VIS, interpretation of the spectra, examples. 10. Qualitative analysis of organic compounds. Instrumental methods of structure analysis: IR, interpretation of the spectra, examples. 11. Qualitative analysis of organic compounds. Instrumental methods of structure analysis: NMR, interpretation of the spectra, examples. 12. Qualitative analysis of organic compounds. Instrumental methods of structure analysis: MS, interpretation of the spectra, examples. MOODLE grade test (60 min). Content of the laboratory exercises 1.+2. Organization of the exercises. Safety rules for a chemical laboratory. Basic operations in the analytical laboratory. Good laboratory practice (GLP). Group reactions of cations - group reagent: HCl, H2SO4, (COOH)2, (NH4)2S,
    NaOH, NH3, KI, CH3COONa. Analysis of an unknown sample. 3.+4. Preliminary test. Group reactions of anions, group reagents: BaCl2, AgNO3, KMnO4, I2, KI. Analysis of an unknown sample. 5.+6. Preliminary test. Analysis of organic compounds, preliminary tests, elemental analysis, determination of the class of solubility. Analysis of two unknown samples. 7.+8. Preliminary test. Physical properties of compounds: measurement of melting point, refractive index, pH. Calculation of analytical concentration of a weak acid from a pH measurement. 9.+10. Preliminary test. Identification of organic compounds from UV-vis spectra. Influence of pH on the absorption spectrum of an acid-base indicator. 11.+12. Preliminary test. Identification of compounds by Infrared spectrometry (IR). Comparison of KBr-tablet technique (transmission mode) and Attenuated total reflection (ATR) technique. Analysis of an unknown sample.
Literature
    required literature
  • Pazourek J., Kapustíková I., Odehnalová K. Cvičení z analytické chemie 1. Analytická chemie kvalitativní. VFU Brno, 2014. URL info
  • Karlíček, R. a kolektiv. Analytická chemie pro farmaceuty. Praha, UK, 2005. info
    recommended literature
  • Šmejkal K, Muselík J, Mokrý P. Laboratorní metody experimentální fytochemie. Brno, 2013. ISBN 978-80-7305-649-0. info
  • MZČR. Český lékopis. Praha, 2009. ISBN 978-80-247-2994-7. info
  • Dohnal, J. a kol. Moderní přístupy k farmaceutické analýze. 3. Farmaceutická analýza v pevné fázi. VFU Brno, 2009. ISBN 978-80-7305-075-7. info
  • Štulík, K. a kolektiv. Analytické separační metody. UK Praha, 2004. info
  • Klouda, P. Moderní analytické metody. Nakladatelství P. Klouda Ostrava, 1996. info
  • Kalous, V. Jak moderní chemie zkoumá strukturu molekul. Praha, 1983. info
Teaching methods
Monologic (reading, lecture, demonstration) Laboratory work
Assessment methods
written grade test; 51% of correct answers is needed to pass
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Listed among pre-requisites of other courses
Teacher's information
http://is.muni.cz/auth/el/pharm/podzim2020/F1AI1_15/index.qwarp
To obtain credit a student must satisfactory complete all exercises, submit protocols from each exercise and successfuly pass a credit test. Topics of questions for the written credit test: Confirmation reactions of analytical chemistry. Group and selective reactions of cations and anions: examples of the most important reactions, reaction conditions. Elementary qualitative analysis, determination of basic physical constants and solubility classes of organic substances. Evidence of oxygen and nitrogen functional groups. Identification of organic substances by instrumental methods: UV-VIS, IR, NMR, MS. Solution of the structure according to spectra (or summary formula and other data).
The course is also listed under the following terms Autumn 2020, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2021, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2021/F1AI1_15