FaF:FDCBO_FAF Bioorganic Chemistry - Course Information

FDCBO_FAF Bioorganic Chemistry

Extent and Intensity

1/1/0. 25 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. PharmDr. Oldřich Farsa, Ph.D. (lecturer)

Guaranteed by

doc. PharmDr. Oldřich Farsa, Ph.D.
Faculty of Pharmacy

Prerequisites (in Czech)

FAKULTA(FaF)

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• Medicinal Chemistry (programme FaF, D-FCH) (2)

Course objectives

Bioorganic chemistry is chemistry of organic biologically active compounds. It is besides medicines which are in detail studied by medicinal chemistry concerned with pesticides used in agriculture (herbicides, fungicides, insecticides, moluscocides, rodenticides...), food additives in which a biologic activity can be specified, chemical combat substances and toxic compounds of all the kind. The discipline studies both qualitative (SAR) a quantitative (QSAR) relationships between structure and activity or toxicity of these compounds. It also deals with their syntheses and metabolism as well as computer modelling of interactions of these molecules with target structures such as such as enzymes, receptors or nucleic acids.

Learning outcomes

A DSP student will acquire an advanced knowledge in the field of biologically active compounds, which cannot considered to be medicines, mainly pesticides, chemical assault substances, industrial poisons and food additives in the range, agreed preliminarily among a student, his/her tutor and a examiner.

Syllabus

• Topics:
  1. Compounds interacting with the vegetative nervous system. Indirect cholihergics - choline esterases inhibitors: insecticides, warfare agents. Choline esterases reactivators. Specific GABA-receptors´ subtypes ligands: insecticides.
  2. Anticoagulants. Rodenticides.
  3. Herbicides. Photosysthesis inhobitors and compounds acting by other mechanisms.
  4. Antimicrobial and antifungal preservatives of foods, drug forms, cosmetics, wood and agricultular fungicides.
  5. Antioxidants for food, pharmaceutical, cosmetic and industrial usage.
  6. Repelents.

Literature

required literature
• Rowe R. et al. Handbook of pharmaceutical excipients. London, 2005. info

recommended literature
• Lushchak V.I., Matviishyn T.M. et al. Pesticide toxicity: a mechanistic approach. Germany, 2018. URL info
• Tarazona J.V., Court-Marques D. et al. Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Germany, 2017. info
• Abou-Donia M.B., Siracuse B., Gupta N., Sobel Sokol A. Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review. England, 2016. info
• Ulrich E.M., Morrison C.N. et al. Chiral pesticides: identification, description, and environmental implications. Unites States, 2012. info
• Hoskovcová M, Halámek E, Kobliha Z. Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series. United Arab Emirates, 2009. info
• Buckingham S.D., Biggin P.C. et al. Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides. 2005. info
• Schmidt R. H., Rodrich G. e. Food Safety Handbook. 2003. ISBN 9780470362570. info
• WAISSER, K. BIOORGANICKÁ CHEMIE. Karolinum, 1998. ISBN 80-7184-547-7. info
• Kuchař M., Rejholec V. Využití kvantitativních vztahů mezi strukturou a biologickou aktivitou. Academia,. Praha, 1987. info

Teaching methods

Methods of work with a text (a textbook, a book, journal articles via internet)

Assessment methods

A marque
Oral exam
Written exam.

Language of instruction

Czech

Further comments (probably available only in Czech)

The course can also be completed outside the examination period.
The course is taught each semester.

Teacher's information

The knowledge of the topics of the discipline in the range which will be preliminarily agreed among the guarantor, Ph.D. student and his/her tutor.

• Enrolment Statistics (Autumn 2021, recent)
  
• Permalink: https://is.muni.cz/course/pharm/autumn2021/FDCBO_FAF