FALF1_13 Theory of Dosage Forms

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
PharmDr. Jan Elbl, Ph.D. (lecturer)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (seminar tutor)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Tue 15:10–16:50 18-122
  • Timetable of Seminar Groups:
FALF1_13/01: Fri 22. 9. to Fri 20. 10. each even Friday 8:00–8:50 18-122, each even Friday 8:50–11:20 18-138; and Fri 3. 11. 8:00–8:50 18-122, J. Muselík
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Obligatory subject presenting the basics in medicament formulation, methods and processes useful for their development, polymers suitable for medical form design, stability testing.
Learning outcomes
After completing the course, the student will be able to:
- identify and classify the dosage form into one of the three generations according to the nature of the drug release;
- describe procedures leading to increased bioavailability of drugs;
- describe the production and evaluation of mucoadhesive systems, ion exchangers and biological dosage forms;
- describe the principles of 3D printing for the preparation of dosage forms;
- describe in vitro-in vivo modelsv in drug development
Syllabus
  • LECTURES:
  • Introduction into the pharmaceutical technology, medical forms and drug delivery, the importance of biopharmacy and pharmacokinetics in formulation and development of pharmaceuticals. Generation of medical forms. Medical forms of the first generation.
  • Medical forms of the second and the third generation.
  • Physico-chemical factors influencing the effect of the drug.
  • Biological factors influencing the effect of the drug.
  • Preformulation studies, drug formulation, drug validation.
  • Increasing bioavailability of poorly water soluble drugs by their modification.
  • Increasing bioavailability of poorly water soluble drugs by technological methods facilitating drug dissolution.
  • Lipophilic formulations for increasing bioavailability of poorly water-soluble drugs.
  • Liquid-solid systems and their application in pharmacy. Medical forms based on these systems.
  • Mucoadhesive systems and their application in pharmacy. Medical forms based on these systems.
  • 3D printing and its application in pharmacy. Medical forms based on this technology.
  • Ion exchangers and their application in pharmacy. Medical forms based on ion exchangers. Production of biological dosage forms.
  • In vitro in vivo models in drug development.

    PRACTICAL TRAINING:
  • Surface tension measurement by stalagmometric method.
  • Preparation and evaluation of mucoadhesive oral films (MOF).
  • Evaluation of aggregate state of suspension.
Literature
    required literature
  • Sinko, P.T., Singh, Y. Martin's Physical Pharmacy 2011. info
Teaching methods
lectures, laboratory exercises
Assessment methods
credit, oral exam
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
Lectures recommended due to lack of suitable literature. Participate in exercises in the full range given by the syllabus and properly prepare protocols from laboratory exercises. Demonstrate ongoing knowledge in the preparation for laboratory exercices. The condition for participation in the exam is to obtain a credit.
The course is also listed under the following terms Autumn 2020, Autumn 2021, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/FALF1_13