FAME1_16 Molecular Biology

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Marie Brázdová, Ph.D. (lecturer)
PharmDr. Zuzana Soldánová (lecturer)
Mgr. Daniel Renčiuk, Ph.D. (lecturer)
Ing. Branislav Ruttkay-Nedecký, Dr. (lecturer)
Mgr. Denis Šubert (lecturer)
PharmDr. Jakub Treml, Ph.D. (lecturer)
Guaranteed by
Mgr. Marie Brázdová, Ph.D.
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Timetable
each odd Friday 12:00–15:20 45-224
Prerequisites
FAKULTA(FaF) || OBOR(MUSFaF)
The knowledge of subject in range of lectures.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of this subject is to provide students with basic information from molecular biology. The ground of lectures is focused on structure of proteins and nucleic acids and functions and relationships of these informational macromolecules in transition of genetic information. Students will familiarise with structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression. The molecular mechanisms of mutagenesis, recombination and transposition, reparation mechanisms and molecular basis of carcinogenesis are explained. The fundament of molecular evolution and theory of life origin on Earth are illustrated. Part of the lectures is focused on molecular biology methods and on applications of molecular biology principles in microbiology, pharmacology, human genetics, epidemiology and epizootology.
Learning outcomes
Basic knowledge of molecular biology forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics, Structure and evolution of genomes. After completing the course, the student will be able to: - identify and summarize important features on the structure of proteins and nucleic acids and the functions and relationships of information macromolecules in the transmission of genetic information; - describe the structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression; - describe the molecular mechanisms of mutagenesis, recombination and transposition, repair mechanisms and the molecular nature of carcinogenesis;
Syllabus
  • 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
    2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
    3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
    4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
    5) Regulation of gene expression, molecular signalling.
    6) RNA interference
    7) Replication, expression of bacterial and animal virus's genes.
    8) Mutagenesis, spontaneous and induced mutation and reversion.
    9) Molecular basis of recombination, recombinantion in genetics.
    10) Transposons, mechanisms of transposition, retroelements, retroviruses.
    11) Reparation and excision mechanisms.
    12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
    13) Cell cycle and apoptosis
Literature
    recommended literature
  • RUSSELL, P.J. iGenetics, A molecular Approach. Pearson, Benjamin Cummings. New York, U.S.A., 2006. info
  • WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Be, 2004. info
  • ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. B, 2002. info
Teaching methods
lectures, videos
Assessment methods
Written examination test - answering questions (to successfully complete 60 %) .
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
- rating from written test at least 60%
The course is also listed under the following terms Autumn 2020, Autumn 2021, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/FAME1_16