FATO1_14 Toxicology

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
MUDr. Marta Chalupová, Ph.D. (lecturer)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
MUDr. Tomáš Parák, Ph.D. (lecturer)
prof. PharmDr. Karel Šmejkal, Ph.D. (lecturer)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
PharmDr. Tereza Kauerová, Ph.D. (seminar tutor)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (seminar tutor)
MUDr. Tomáš Parák, Ph.D. (seminar tutor)
PharmDr. Lenka Paráková, Ph.D. (seminar tutor)
PharmDr. Zuzana Široká, Ph.D. (lecturer)
Guaranteed by
doc. MVDr. Pavel Suchý, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Timetable
Tue 9:55–11:35 45-221
  • Timetable of Seminar Groups:
FATO1_14/01: each even Tuesday 11:50–13:30 45-221
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of this subject is to provide students basic knowledge in the area of toxicology. Modern toxicology is an interdisciplinary scientific discipline focused on interactions of xenobiotics with living systems, which lead to their damage or death. The subject incorporates with various disciplines, which are taught in previous years (biology, morphology, physiology and human pathophysiology).
Learning outcomes
After completing the course the student is able to define the course Toxicology and have knowledge of basic toxicological terms. The student is able to describe in general the dangerous characteristics of substances, the mechanisms of their toxic effect and kinetics. The student has a comprehensive overview of the hazards of toxicologically important inorganic, organic and natural substances and a basic overview of the toxicity of selected pesticides, radionuclides and drugs. He orients himself in related legal regulations and has an overview of methods for testing the hazardous properties of substances.
Syllabus
  • Lectures

    1. Toxicology, definition and history, general terminology, classification of toxins

    2. Relationship between the substance, dose and toxic effect, toxicokinetics

    3. Mechanisms of toxic effect, factors influencing the toxic effect

    4. Toxicologically important inorganic substances

    5. Toxicologically important organic substances (I)


    6. Pesticides and their residues in food, ecotoxicology

    7. Toxicologically important natural substances I (herbal toxins, toxins in algae and cyanobacteria, mycotoxins)

    8. Toxicologically important natural substances II (bacterial toxins and animal toxins)

    9. Toxicology of medicinal drugs, most common medicinal drug poisonings

    10. Chemical warfare agents, radiotoxicology

    11. Drug abuse, toxicological view on newly synthesized drugs

    12. Intoxication therapy, general rules

    13. Final lesson - classification test


    Exercises

    1. Organisation of lessons
    Introduction into the experimental evaluation of toxicity

    2. In silico evaluation of toxicity
    The READ Across method, alternative methods for the assessment of toxicity, QSAR Tool Box, constructing valid QSAR models, the use of predictive models

    3. In vitro evaluation of toxicity
    Toxicity mechanisms on cellular level and their evaluation, tests of cytotoxicity and genotoxicity, determining EC50

    4. In vivo evaluation of toxicity
    Determining systemic toxicity and toxicity after repeated administering, testing local effect (dermal irritability, sensibilisation, eye irritation, implantation), pyrogenicity tests, carcinogenicity and reproduction toxicity)

    5. Ecotoxicology
    Circulation of pollutants in the environment, biomonitoring, effect on organisms, degradability, absorption/desorption. Drug residues in the environment.

    5. Guided visit of a toxicological laboratory
    Good laboratory practice, interpreting results of tests, most common findings, case studies

    6. Consultation
Literature
    required literature
  • Reichl, F.X. - Ritter, L. Illustrated Handbook of Toxicology. Thiemme Stuttgart, 2011. ISBN 978-3-13-126921-8. info
    recommended literature
  • https://toxoer.files.wordpress.com/2018/02/toxoer-challenges-in-open-education-resources_2018_toxicology.pdf
  • Mulder, Gerard J, Dencker, Lennart. Pharmaceutical Toxicology. 2006. ISBN 978 0 85369 593 6. info
  • Phillip L. Williams. PRINCIPLES OF TOXICOLOGY. 2000. ISBN 0-471-29321-0. URL info
  • Ted A. Loomis, M.D., Ph.D., and A. Wallace Hayes, Ph.D. Loomis's Essentials of Toxicology. 1996. ISBN 978-0-12-455625-6. URL info
Teaching methods
lectures, seminars
Assessment methods
Classification test at the end of the semester. or test questions, the student always chooses one correct answer from the options offered, for which 1 point is added. No points will be deducted for an unfilled or incorrectly answered question. The condition for passing the credit test is to achieve at least 50% of the maximum possible number of points.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
In accordance with study and examining order of credit system of MUNI Brno.
The course is also listed under the following terms Spring 2020, Autumn 2020, Autumn 2021, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/FATO1_14