FDCAL_FAF Analysis of Drugs

Faculty of Pharmacy
Autumn 2024
Extent and Intensity
1/1/0. 25 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (lecturer)
Guaranteed by
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA
Faculty of Pharmacy
Prerequisites (in Czech)
FAKULTA(FaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to deepen students' knowledge of methods of work and possibilities of application of methods of analytical chemistry for the field of drug analysis. The main emphasis is placed on the analysis of drugs, which is directly related to the thematic focus of the student's dissertation. The student is guided to master the entire analytical system from sampling to analytical interpretation of results, including the use of relevant statistical methods.
Learning outcomes
Learning outcomes of the course are theoretical knowledge and practical experience of students of methods used for comprehensive evaluation of drugs and medicinal products in accordance with applicable regulations in the Czech Republic and the EU. The content of the course is based on the requirements of the European Pharmacopoeia as a supranational legal norm. The graduate of the course Drug Analysis is to master the basic procedures and methods of pharmacopoeial evaluation of drugs. Evidence of drugs based on physical constants, using instrumental-analytical methods and chemical reactions. To control group and selective reactions of structural types of drugs within pharmacotherapeutic groups. He has mastered the technique of limit tests for the purity of drugs, volumetric and gravimetric determination of drugs and pharmaceutical excipients. He should be able to perform analytical evaluation of drugs and medicinal products using chromatographic, spectral and electroanalytical methods. He should be able to perform experimental studies of medicinal products, evaluation of relevant physical and chemical parameters, including detection and quantification of degradation products, according to the given procedure.
Syllabus
  • Drug Identification and Drug Assay:
    - detection and quantification of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation),
    - detection and quantification of drugs using of physicochemical methods (spectral, separational, electrochemical methods),
    Purity and stability of drugs
Literature
    recommended literature
  • Český lékopis 2017. 2017. ISBN 859-404-924-045-6. info
  • Moderní přístupy k farmaceutické analýze, Strukturní analýza léčiv. VFU Brno, 2009. ISBN 9788073050580. info
  • Moderní přístupy k farmaceutické analýze, Analýza chirálních léčiv. 2008. ISBN 9788073050566. info
  • ASHUTOSH KAR. Pharmaceutical Drug Analysis. New Age International (P) Ltd., Publishers, 2005. ISBN 9788122427189. info
Teaching methods
theoretical training, individual consultations, discussion
Assessment methods
exam
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
Teaching takes the form of personal consultations and other educational activities, that are recommended by the guarantor of the course. The course is done using self-studies. Practical application of acquired knowledge assists you to attain the exact techniques for you doctoral thesses.
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Autumn 2023, Spring 2024, Spring 2025.
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