FDGFZ_FAF Physico-chemical Fundamentals of NMR

Faculty of Pharmacy
Spring 2020
Extent and Intensity
1/0/0. 15 credit(s). Type of Completion: zk (examination).
Guaranteed by
doc. Ing. Pavel Bobáľ, CSc.
Faculty of Pharmacy
Prerequisites
The knowledge of basics of inorganic and organic chemistry, analytical and physical chemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Learning outcomes of the course aim the subject on the introduction of the student of DSP into nuclear magnetic resonance, with special focus on the identification of secondary metabolites of plants. The subject presents possibilities of using NMR and individual experiments in solving the structures of particular isolated compounds. Acquired knowledge will enable them to orientate in modern methods of NMR spectroscopy used in organic and inorganic chemistry, biochemistry and methods of modern structural analysis.
Learning outcomes
Understand theoretical bases of NMR and the ability to practically use available NMR techniques to elucidate the structure of organic compounds
Syllabus
  • Subject Physico-chemical Fundamentals of NMR is designed to introduce the techniques particularly 1H, 13C NMR spectroscopy, as powerful tools for structure elucidation of organic compounds. A brief introduction to the physical principles of NMR spectroscopy will be followed by extensive analysis and discussion of NMR parameters such as chemical shift, coupling constants, splitting patterns, etc. The second half of the course is dedicated to the use of multi-pulse experiments (spin decoupling, NOE, APT, INEPT, DEPT etc.) and 2-dimensional techniques (COSY, NOESY, ROESY, etc.) in structure elucidation of complex natural products.
Literature
    required literature
  • SILVERSTEIN, Robert M. Spectrometric identification of organic compounds. 8th ed. Hoboken: Wiley,, 2015. ISBN 978-0-470-61637-6. info
  • PRETSCH, Ernö, P. BU?HLMANN a M. BADERTSCHER. Structure determination of organic compounds: tables of spectral data. 4th, rev. and enl. ed. Berlin: Springer, 2009. ISBN 978-3-540-93809-5. info
Teaching methods (in Czech)
Dialogická (diskuze, rozhovor, brainstorming)
Demonstrace
Assessment methods (in Czech)
Ústní zkouška
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Teacher's information
Mastering physicochemical bases of NMR
Consultation with the teacher
Practical application of acquired knowledge
The course is done using self-studies, personal communication, and consultations with the lecturer
The course is also listed under the following terms Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Autumn 2023, Spring 2024, Autumn 2024, Spring 2025.
  • Enrolment Statistics (Spring 2020, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2020/FDGFZ_FAF