F1FO2_13 Dosage Forms and Biopharmacy II

Faculty of Pharmacy
Spring 2021
Extent and Intensity
3/6/0. 11 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Aleš Franc, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
doc. PharmDr. Ruta Masteiková, CSc. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
PharmDr. Jakub Vysloužil, Ph.D. (lecturer)
doc. PharmDr. Aleš Franc, Ph.D. (seminar tutor)
doc. PharmDr. Jan Gajdziok, Ph.D. (seminar tutor)
doc. PharmDr. Kateřina Kubová, Ph.D. (seminar tutor)
doc. PharmDr. Ruta Masteiková, CSc. (seminar tutor)
PharmDr. Miroslava Pavelková, Ph.D. (seminar tutor)
PharmDr. Jakub Vysloužil, Ph.D. (seminar tutor)
PharmDr. Kateřina Brückner, Ph.D. (seminar tutor)
Mgr. Martin Dominik (seminar tutor)
PharmDr. Nicole Fülöpová (seminar tutor)
PharmDr. Michaela Garajová (seminar tutor)
PharmDr. Martina Holická, Ph.D. (seminar tutor)
PharmDr. Hana Hořavová (seminar tutor)
Guaranteed by
doc. PharmDr. Kateřina Kubová, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Supplier department: Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Thu 13:00–15:15 44-056
  • Timetable of Seminar Groups:
F1FO2_13/01: Mon 7:30–12:00 18-138, R. Masteiková
F1FO2_13/02: Mon 7:30–9:00 18-122, Mon 9:00–12:00 18-107, M. Garajová
F1FO2_13/03: Mon 13:00–17:30 18-138, J. Gajdziok
F1FO2_13/04: Mon 13:00–14:30 18-122, Mon 14:30–17:30 18-107, K. Kubová
F1FO2_13/05: Tue 7:30–12:00 18-138, K. Brückner
F1FO2_13/06: Tue 7:30–9:00 18-122, Tue 9:00–12:00 18-107, N. Fülöpová
F1FO2_13/07: Wed 7:30–12:00 18-138, J. Vysloužil
F1FO2_13/08: Wed 7:30–9:00 18-122, Wed 9:00–12:00 18-107, M. Holická
F1FO2_13/09: Wed 13:00–17:30 18-138, A. Franc
F1FO2_13/10: Wed 13:00–13:45 18-122, Wed 13:45–17:30 18-107, M. Dominik
F1FO2_13/11: Thu 7:30–12:00 18-138, M. Pavelková
F1FO2_13/12: Thu 7:30–9:00 18-122, Thu 9:00–12:00 18-107, H. Hořavová
Prerequisites
Credit from the subject Pharmaceutical Forms and Biopharmacy I
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 165 student(s).
Current registration and enrolment status: enrolled: 0/165, only registered: 0/165, only registered with preference (fields directly associated with the programme): 0/165
fields of study / plans the course is directly associated with
Course objectives
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Learning outcomes
After completing the course, student will: • -know basic calculations for a given area; • - theoretically know the classification, requirements, excipients, technological process of preparation and production of solid dosage forms, including their evaluation; • - know the basic aspects of dosage forms in relation to the drug bioavailability • - practically know the preparation of semisolid and solid dosage forms in pharmacy conditions;
Syllabus
  • SYLLABUS OF LECTURES
    1. Rectal dosage forms - definition, classification, properties. Suppositories, excipients, preparation, quality evaluation.
    2. Vaginal dosage forms - definition, classification, properties, excipients, quality evaluation.
    3. Granules, basic granulation techniques and equipment. Quality evaluation of powders and granules.
    4. Tablets - classification, basic compression techniques. Excipients for tablets. Quality evaluation and use.
    5.Coated products - classification, basic coating techniques, quality evaluation and use.
    6. Incompatibilities in semisolid and solid dosage forms.
    7.Pharmaceutical packaging.
    8. The principles of good manufacturing practice.
    9. Capsules - classification, production, excipients, quality evaluation and use.
    10. Aerodispersions - definition, classification, properties. Basic types of inhalation systems. Excipients for aerodispersions. Quality evaluation and use.
    11.Transdermal preparations. Basic types of transdermal therapeutic systems. Excipients for transdermal preparations. Quality evaluation and use.
    12. Oral dosage forms with controlled drug release.
    13. Lékové mikroformy. Definice, klasifikace, charakteristika, technologie výroby, hodnocení jakosti.

    PRACTICAL TRAINING
    1. Ointments. Preparation and evaluation.
    2. Creams. Preparation and evaluation.
    3. Pastes and gels. Preparation and evaluation.
    4. Rectal suppositories. Determination of base replacement coefficient, calculations, preparation of suppositories with known base replacement coefficient.
    5. Rectal suppositories. Experimental determination of base replacement coefficient. Preparation of suppositories with unknown base replacement coefficient.
    6. Vaginal dosage forms. Preparation and evaluation.
    7. Technological procedures in preparation of complicated prescriptions of semisolid dosage forms, powders and suppositories.
    8. Solving of incompatibilities in prescriptions on semisolid and solid dosage forms, powders and suppositories, preparations according to prescriptions.
    9. Alternative training.
    10. Production of tablets by direct compression.
    11. Granulation technique.
    12. Production of tablets from granules prepared by fluid bed granulation technique.
    13. Evaluation of solid dosage forms.
    14. Test and check training. Awarding credits.

Literature
    required literature
  • Český lékopis - platné vydání a doplňky. info
  • Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info
    not specified
  • Česká a slovenská farmacie. info
  • Zathurecký, L., Chalabala, M., Janků, I., Modr., Z. Biofarmácia a farmakokinetika. Osveta Martin, 1989. ISBN 80-217-0068-8. info
  • Chalabala, M., Heinrich, J. Základy výroby a tvorby liekov. Osveta Martin, 1988. info
Teaching methods

1Lectures
2Lab training
3 Homework
Assessment methods

1.Written test
2.Systematic observation of student during lab training
3.Practical test of student skills
3.Oral examination - a prerequisite for participation in the exam is to meet credit F1FO1-13 and F1F02-13
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
https://is.muni.cz/auth/ucitel/?fakulta=1416;obdobi=8104;predmet=1347018
Lectures are recommended due to the lack of suitable literature.
Practical labs are mandatory.
The course is also listed under the following terms Spring 2020, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2021, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2021/F1FO2_13