FAFO2_13 Dosage Forms and Biopharmacy II

Farmaceutická fakulta
jaro 2025
Rozsah
3/6/0. 11 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. PharmDr. Aleš Franc, Ph.D. (přednášející)
doc. PharmDr. Jan Gajdziok, Ph.D. (přednášející)
doc. PharmDr. Kateřina Kubová, Ph.D. (přednášející)
PharmDr. Jakub Vysloužil, Ph.D. (přednášející)
doc. PharmDr. Aleš Franc, Ph.D. (cvičící)
doc. PharmDr. Jan Gajdziok, Ph.D. (cvičící)
doc. PharmDr. Kateřina Kubová, Ph.D. (cvičící)
PharmDr. Jakub Vysloužil, Ph.D. (cvičící)
PharmDr. Kateřina Brückner, Ph.D. (cvičící)
PharmDr. Miroslava Pavelková, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Garance
doc. PharmDr. Kateřina Kubová, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Předpoklady
FAFO1_13 Dosage Forms and Biopharmacy
Dosage Forms and Biopharmacy I
Students can study this course only after completing the course Dosage Forms and Biopharmacy I
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 20 stud.
Momentální stav registrace a zápisu: zapsáno: 0/20, pouze zareg.: 0/20
Mateřské obory/plány
Cíle předmětu
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Výstupy z učení
After completing the course, the student will:
- describe the theoretical aspects of semisolid dosage forms formulation and quality testing;
- describe the classification, requirements, excipients, and technological process of preparation and production of solid dosage forms, including their evaluation;
- theoretically describe the classification, requirements, excipients, technological process of preparation and production of dosage forms with controlled drug release, including their evaluation;
- know the basic aspects of semisolid and solid dosage forms about the drug bioavailability;
- describe the main conditions of GMP
- recognize selected incompatibilities in liquid and semisolid dosage forms and adjust the composition of pharmaceutical products;
- prepare semisolid (ointments, cremes, pastes, gels) and solid dosage forms (powders, granules, capsules, suppositories, vaginal globules) in pharmacy conditions
Osnova
  • Topic of lecture
    Dosage forms for rectal application
    Dosage forms for vaginal application
    Granules, granulation methods. Evaluation of powders and granules
    Tablets, their production, and evaluation
    Pharmaceutical packaging
    Pharmaceutical incompatibilities in dosage forms
    Coated products, their production and evaluation
    Development of new drugs from galenical perspective
    Multiple-unit drug delivery systems
    Pharmaceutical aerodispersions
    Transdermal preparations
    Validation in pharmaceutical technology
    Controlled drug release
    Good manufacturing practice in pharmacy

    Practical labs
    Semisolid dosage forms - Ointments
    Semisolid dosage forms - Creams
    Semisolid dosage forms - Pastes, Gels
    Test - semisolid preparation. Rectal and vaginal dosage forms - theoretical aspect of preparation
    Rectal and vaginal dosage forms
    Technological processes in preparation of difficult prescriptions I. Test - suppositories, vaginal globules.
    Technological processes in preparation of difficult prescriptions II.
    Divided and non-divided pharmaceutical powders. Preparation and evaluation
    Alternative training
    Wet and melt granulations
    Tablets preparation by direct compression
    Evaluation of solid dosage forms
    Fluid bed granulation
    Credit test, Laboratory skills testing
Literatura
    doporučená literatura
  • European Pharmacopoeia 11
  • MAHATO, Ram I. Pharmaceutical dosage forms and drug delivery. Boca Raton, FL: CRC Press, 2007, xxxi, 300. ISBN 0849392853. info
  • Aqueous polymeric coatings for pharmaceutical dosage forms. Edited by Linda A. Felton. Fourth edition. Boca Raton, FL: CRC Press, 2017, 1 online. ISBN 9781315369938. URL info
  • Handbook of Pharmaceutical Excipients. Great Britain, 2006. ISBN 1-58212-058-7. info
Výukové metody
1Lectures - powerpoint presentations
2 Individual lab training - practical skills
Metody hodnocení
Intermediate tests in laboratory classes
Systematic observation of the student during laboratory classes, preparation of reports following the teacher's instructions
Credit test (credit test has two parts, part 1 - pharmaceutical calculations (limit for passing 75%), part 2 - test - closed and open questions from knowledge from lectures and laboratory classes (limit for passing - 60%).
Practical testing is conducted to evaluate students' skills as part of the credit assessment.
Oral examination (study topics are available in the study materials in IS MU)
Vyučovací jazyk
Angličtina
Informace učitele
Lectures are recommended due to the lack of suitable literature. Students can study this course only after completing the course Dosage Forms and Biopharmacy I
All study materials are available in IS MU.
Další komentáře
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024.