FDTLF_FAF Dosage Forms with Controlled Drug Release and Targeting

Faculty of Pharmacy
Spring 2025
Extent and Intensity
1/1/0. 25 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
doc. PharmDr. Ruta Masteiková, CSc. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
Guaranteed by
doc. PharmDr. Kateřina Kubová, Ph.D.
Faculty of Pharmacy
Prerequisites (in Czech)
FAKULTA(FaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Expanding the knowledge of the student focusing on modern medical forms, with different profiles of drug release and their use in the current pharmacotherapy of local and systemic diseases, obtained mainly from world databases containing knowledge from scientific publications especially of foreign research experts and institutions and increasing the ability of the student to process this knowledge into research texts focusing on the content of the study program.
Learning outcomes
After completing the course, the student will be able to: -differentize the basic technological principles of modern dosage forms and their production
-estimate the function of excipients in dosage form
-estimate the behavior of a modern dosage form in the body
-estimate the benefit of these forms for pharmacotherapy
-suggest a suitable modification of the dosage form to ensure the desired drug release profile and site of its action
Syllabus
  • Importance of dosage forms with controlled and targeted drug transport in therapy.
    Matrix systems for oral and other usage, their manufacturing technology, kinetics and release mechanism.
    Multiple dosage forms - their manufacturing technology and usage in the pharmacotherapy.
    Microparticle dosage forms - their manufacturing technology and usage in the pharmacotherapy.
    Dosage forms with delayed drug release - their manufacturing technology and in the usage pharmacotherapy.
    Physiological factors of GIT in relation to modern dosage forms.
    pH-dependent polymers in pharmaceutical technology.
    Dosage forms for the treatment of colon diseases and absorption of drug from the area of the colon.
    Modern dosage forms for long-term drug delivery for topical therapy
    Modern dosage forms for long-term drug delivery for systemic therapy.
Literature
    required literature
  • NAVRÁTILOVÁ RADINOVÁ, Eva, Eliska MASKOVA, Kateřina KUBOVÁ and Jakub VYSLOUŽIL. Nanočástice jako léková forma v praxi (Nanoparticles as a Dosage Form in Practice). CHEMICKÉ LISTY. Praha: CHEMICKÉ LISTY, 2023, vol. 117, No 10, p. 604-612. ISSN 0009-2770. Available from: https://dx.doi.org/10.54779/chl20230604. URL info
  • BÍLIK, Tomáš, Miroslava PAVELKOVÁ, Kateřina KUBOVÁ and Jakub VYSLOUŽIL. Dose dumping pevných perorálních lékových forem s modifikovaným uvolňováním (Dose dumping of modified-release solid oral dosage forms). Cesko-Slovenska Farmacie. Ceska Lekarska Spolecnost J.E. Purkyne/Czech Medical Association, 2022, vol. 71, No 6, p. 251-258. ISSN 1210-7816. URL info
  • ROHAĽOVÁ, Simona, Jan GAJDZIOK, Tomáš WOLASCHKA and David VETCHÝ. Polyméry reagujúce na stimuly pre prípravu in situ gélov (Stimuli-responsive Polymers for the Preparation of in situ Gels). CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2021, vol. 115, No 1, p. 25-31. ISSN 0009-2770. URL info
  • GAJDZIOK, Jan and David VETCHÝ. Orodispersible Films, Technologies of Their Manufacturing and Specific Excipients. CHEMICKE LISTY. 2016. info
  • KUBOVÁ, Kateřina and David VETCHÝ. Využití (meth)akrylátových kopolymerů v technologii matricových tablet s řízeným uvolňováním léčiva. Chemické listy. 2015. info
    recommended literature
  • HOLICKÁ, Martina, Martina NAISEROVÁ, Jakub VYSLOUŽIL, Kateřina KUBOVÁ, David VETCHÝ, Josef MAŠEK and Eliška MAŠKOVÁ. Využití droplet-based mikrofluidních technik při přípravě mikročástic (Use of droplet-based microfluidic techniques in the preparation of microparticles). Česká a slovenská farmacie. Czech Medical Association J.E. Purkyne, 2021, vol. 70, No 5, p. 155-163. ISSN 1210-7816. Available from: https://dx.doi.org/10.5817/CSF2021-5-155. URL info
  • GAJDZIOK, Jan and David VETCHÝ. Texture Analysis as a Modern Approach to Evaluate Dosage Forms and Medical Devices. CHEMICKE LISTY. 2017. info
  • FRANC, Aleš, Jan GAJDZIOK and David VETCHÝ. Biorelevant dissolution media simulating conditions in gastrointestinal tract. CHEMICKÉ LISTY. 2016. info
  • FRANC, Aleš and Jan MUSELÍK. Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes. ACTA PHARMACEUTICA. 2016. Available from: https://dx.doi.org/10.1515/acph-2016-0017. info
Teaching methods
Teaching is by way of consultation.
Current literature will be sent to the student by the guarantor upon request.
Assessment methods
oral examination
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
Teaching is by way of consultation.
Current literature will be sent to the student by the guarantor upon request.
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Autumn 2023, Spring 2024, Autumn 2024.
  • Enrolment Statistics (Spring 2025, recent)
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