C5920 Good Laboratory Practice

Faculty of Science
Autumn 2005
Extent and Intensity
1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Luděk Bláha, Ph.D. (lecturer)
prof. RNDr. Ivan Holoubek, CSc. (lecturer)
prof. RNDr. Jana Klánová, Ph.D. (lecturer)
RNDr. Pavel Kořínek, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Ivan Holoubek, CSc.
Chemistry Section – Faculty of Science
Timetable
Wed 14:00–14:50 Kontaktujte učitele
Prerequisites
Introductory course on Analytical Chemistry or an equivalent
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Principles and goals of GLP are introduced, fundamental terms and standards are quoted. Organisation of laboratory and work conditions, laboratory accreditation and proficiency testing are discussed. Following part deals with equipment validation, validation of analytical system and those of analytical methods as well as with performance characteristics of analytical method and evaluation of results. In a closing part, fundamentals of good sampling practice inclusive of sampling techniques for homogeneous and nonhomogeneous objects, design and evaluation of sampling plan with emphasis on environmental sampling are given. Besides general topics and terms, the course is oriented to the field of analytical chemistry / environmental analytical chemistry.
Syllabus
  • I. GLP principles and goals. Historical background, quality assurance and quality management. II. Key provisions. Organisation of laboratory, conditions. III. Laboratory accreditation. ČSN EN ISO/IEC 17025 Standard, terminology. IV. Proficiency testing. Methodics. V. Validation and testing. Validation of equipment, method, analytical system, and data. VI. Validation of analytical methods. VII. Estimation of performance characteristics. Documentation of an analytical method. VIII. Evaluation of results in respect to limit values. Control charts. IX. Principles of good sampling practice. Homogenous and heterogeneous objects, randomised and segregated objects. Sampling errors and sampling plan. X. Sampling techniques. Homogeneity test. Sampling of nonhomogenous objects. Assurance of sampling randomness. Systematic sampling of nonhomogenous materials. XI. Design and evaluation of a sampling plan. Evaluation of sampling precision and trueness. Documentation of sampling. XII. Environmental sampling.
Literature
  • CROSBY, N. T. and F. E. PRICHARD. Quality in the Analytical Laboratory. Chichester: J. Wiley, 1995. Analytical Chemistry by Open Learning (Series). ISBN 0 471 95470 5. info
  • MESTEK, O. and L. NONDEK. Zásady správného odběru vzorků pro analýzu životního prostředí (Principles of Good Sampling Practice in Environmental Analysis). Praha: Eurachem - ČR, 1995. Kvalimetrie, 4. ISBN 80-901868-0-7. info
Assessment methods (in Czech)
přednášky, týdně, písemný test, kolokvium
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018.
  • Enrolment Statistics (Autumn 2005, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2005/C5920