Bi0580 Developmetal genetics

Faculty of Science
Autumn 2008
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Boris Vyskot, DrSc. (lecturer), prof. RNDr. Jiří Doškař, CSc. (deputy)
Guaranteed by
prof. RNDr. Jiří Doškař, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Boris Vyskot, DrSc.
Timetable
Mon 14:00–15:50 BFU
Prerequisites
(SOUHLAS || Ex_3162 Obecná genetika || Imp_9126 Obecná genetika || B1900 Basic genetics || BMB32 Basic genetics || B6730 Basic genetics || B8470 Genetics || B3060 Basic genetics || Bi3060 Basic genetics ) && ( Ex_3065 Molekulární biologie || Imp_9115 Molekulární biologie || B3120 Molecular and cell biology || B4030 Molecular biology || B5740 Molecular biology || B6130 Molecular biology || B7940 Molecular biology || B4020 Molecular biology || Bi4020 Molecular biology ) && ( Bi6081 Bakalářská státní závěrečná zkouška z Molekulární biologie a genetiky || Bi6087 Bakalářská státní závěrečná zkouška z Buněčné a molekulární diagnostiky || SOUHLAS)
Foreign students are welcome (a relevant literature in English is available).
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 8 fields of study the course is directly associated with, display
Course objectives
Developmental genetics is presented as a global survey of principles of developmental processes. It is also presented as comparative science in order to demonstrate common features of developmental processes in phylogenetically distant groups of organisms. We will focus on genetic and epigenetic fundamentals of developmental processes on molecular level. The topic is divided into ten chapters and students receive their adequate e-presentations.
Syllabus
  • (1) General principles of developmental genetics, history, embryonic induction (Spemann), models of flags (Wolpert), reaction-diffuse model of development (Turing), regulative and mosaic development, homeosis (Bateson, Goethe), programmed cell death, preformism and epigenesis (Aristotle), germ-line (Weismann), genes with maternal effects, morphalaxis and epimorphosis (2) Developmental and epigenetic processes in bacteria (Bacillus subtilis), fungi (yeast, Dictyostellium) and primitive animal models (Paramecium, Hydra, Caenorhabditis) (3) Flatworms – rediscovered model of developmental biology: regeneration, neurobiology, allometry, RNA-interference (4) Drosophila melanogaster – the queen of developmental genetics: genetic control cascade of embryogenesis, maternal and zygotic genes, homeotic genes, colinearity, imaginal discs, homeotic transdetermination (5) Deuterostomia as important models for developmental studies: sea urchin, fish, amphibians, birds, mammals (6) Medical aspects of developmental biology: therapy of infertility, malformations, teratogenesis, candidate genes, position cloning, stem cells, DNA therapy, epigenetic diseases (7) Alternative models of plant developmental genetics: Anabaena, Acetabularia, Chlamydomonas, Volvox, Fucus, Marchantia, Physcomitrella, Ceratopteris, Populus, Antirrhinum, Linaria, Linum, Craterostigma, Zinnia, Silene, Zea, Oryza, Brachypodium, Gagea, Eleocharis, orchids (8) Arabidopsis thaliana model: gametophye and sporophyte, imprinting in endosperm, control of embryogenesis, regulative development, control of flowering, MADS-box genes, homeobox genes, Polycomb proteins (Medea), paramutations, epimutations (9) Sex and its determination, genetically, hormone and epigenetically controlled sexuality, structure and evolution of sex chromosomes, gynandromorphy, dioecy, X- and Y-linked inheritance, molecular mechanisms of sex determination (10) Principles of epigenetic inheritance, mechanisms of epigenetic processes, evolutionary and developmental processes (or evo/devo): heterotopic changes, heterochronic changes, environmental adaptation
Literature
  • B. Vyskot: Přehled vývojové biologie a genetiky. Skriptum, ÚMG AV Praha, 1999 (ISBN 80-902588-1-6)
Assessment methods
oral exam
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Teacher's information
http://www.ibp.cz/labs/PDG/
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Spring 2003, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2008, recent)
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