PřF:C7185 Neurochemistry - Course Information

C7185 Neurochemistry

Extent and Intensity

2/0/0. 4 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).

Teacher(s)

prof. RNDr. Omar Šerý, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Omar Šerý, Ph.D.
Department of Biochemistry – Chemistry Section – Faculty of Science

Timetable

Fri 11:00–12:50 C05/114

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 16 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to give information to students about basic knowledge of modern neurobiology with special focus on molecular basis of psychiatric diseases.

Syllabus

• 1. History of neurosciences: histology, physiology, phrenology, functional anatomy, pharmacology, genetics, molecular biology, molecular psychiatry, psychology 2. Neuron, nervous system, anatomy of CNS: neuron, glial cell, CNS, peripheral nervous system, brain. 3. The development of neural system, functional neuroanatomy: neural plate, embryonal induction, BMP, stereotropism-resonance, growth cone, functional asymetry of bran hemispheres, Wernicke center, Broca center, Brodman, Penfield, Ojeman, Posner, motivation, Papez, emotions. 4. Memory: types of memory, experiments of Penfield, patients of Brenda Milner, hipocampus, amygdala, experiments on Aplysia, Kandel and Nobel price 5. Neurotransmitter systems and psychopharmacology: Glycine, glutamate, dopamine, serotonin, noradrenalin, acetylcholine, endogenous opioids, GABA and their receptors. Psychopharmacs and their influences on CNS. 6. Methods of the research of the brain: neuroimagining methods, CT, MRI, SPECT, PET, EEG, molecular psychiatry, DNA chips. 7. Molecular psychiatry – schizophrenia: symptoms and diagnostics, simplex, paranoid, hebephrenic and catatonic, neuroimagining studies, dopaminergic hypothesis, neurodevelopmental hypothesis, autoimmunity hypothesis, theory of sleeping lesion, genetics, molecular basis of schizophrenia. 8. Molecular psychiatry – affective disorders, classification, symptoms and diagnostics of affective disorders, manic episode, depressive episode, neuroimagining studies, monoamine theory, gabaergic theory, genetics and molecular basis 9. Molecular psychiatry – alcoholism and ADHD: dispositions to the alcoholism, social factors, psychobiologic factors, genetics, molecular studies, ADHD and symptoms and diagnostics, neurobiology of ADHD, neuroimagining studies, genetics, molecular basis. 10. Molecular psychiatry – Alzheimer disease, sexual behavior: Alois Alzheimer, incidence of Alzheimer disease, risk factors, senile plaques, symptoms, diagnostics and the treatment, genetics, molecular basis, sexual differentiation of the brain, testosterone, estrogens, masculinisation of the brain, protective hypothesis, alpha-fetoprotein, transsexuality, Schwaab research, homosexuality, nature-nurture?

Literature

• KOUKOLÍK, František. Lidský mozek :funkční systémy : norma a poruchy. 2., aktualiz. a rozš. vyd. Praha: Portál, 2002, 451 s. ISBN 80-7178-632-2. info
• RABOCH, Jiří and Petr ZVOLSKÝ. Psychiatrie. 1st ed. Praha: Galén, 2002, 622 pp. ISBN 80-7262-140-8. info
• FIŠAR, Zdeněk. Vybrané kapitoly z biologické psychiatrie. Edited by Roman Jirák. Vyd. 1. Praha: Grada, 2001, 315 s. ISBN 8024700611. info
• Principles of neural science. Edited by Eric R. Kandel - James H. Schwartz - Thomas M. Jessell. 3rd ed. East Norwalk: Appleton and Lange, 1991, xliv, 1135. ISBN 0-8385-8034-3. info

Assessment methods

Advanced course, oral exam

Language of instruction

Czech

• Enrolment Statistics (Autumn 2008, recent)
  
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