Bi5000 Introduction to bioinformatics

Faculty of Science
Autumn 2009
Extent and Intensity
1/1/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Roman Pantůček, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Roman Pantůček, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Roman Pantůček, Ph.D.
Timetable
Tue 10:00–11:50 G2,02003
Prerequisites
Ex_3065 Molekulární biologie || Imp_9115 Molekulární biologie || B3120 Molecular and cell biology || B4030 Molecular biology || B5740 Molecular biology || B6130 Molecular biology || B7940 Molecular biology || B4020 Molecular biology || Bi4020 Molecular biology
Basic course of molecular biology (eg. Bi4020).
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of this course is to understanding principles of the computational tools for analysis of nucleic acids and protein sequences. Students should be able to exploit information resources for molecular biology available on internet, i.e. molecular biology databases and different computational tools for their analysis. At the end of the course the students are able manipulate in silico with nucteotide and protein sequences, design primers, perform pair and multiple sequence comparisons and phylogenetical studies, anotate newly determined sequences and submit sequences to public databases.
Syllabus
  • Databases for molecular biology.
  • DNA sequencing techniques.
  • Manipulation with sequence data.
  • Tools for local sequence alignment.
  • Multiple alignment.
  • Comparative genomics.
  • Computational gene finding.
  • Protein identification databases.
  • Prediction of secondary RNA structure.
  • Submiting of genomic sequence to primary database.
  • Phylogenetic analysis based on nucleotide and protein sequences.
  • Image analysis of 1D electrophoretic gels.
Literature
  • CVRČKOVÁ, Fatima. Úvod do praktické bioinformatiky. Praha: Academia, 2006, 150 pp. ISBN 80-200-1360-1. info
  • Bioinformatics : methods and protocols. Edited by Stephen Misener - Stephen A. Krawetz. Totowa, New Jersey: Humana Press, 2000, xi, 500 s. ISBN 0-86903-732-0. info
  • ATTWOOD, Teresa K. and David J. PARRY-SMITH. Introduction to bioinformatics. 1st pub. Essex: Longman, 1999, xx, 218. ISBN 0582327881. info
  • Bioinformatics : a practical guide to the analysis of genes and proteins. Edited by Andreas D. Baxevanis - Francis B.F. Ouellette. New York: Wiley-Interscience, 1998, xiv, 370 s. ISBN 0-471-19196-5. info
Teaching methods
Weekly lectures and exercises, homeworks concerning each practical topic.
Assessment methods
Examination is based on written test composed of 20 questions. Correct answering of at least 60% of them is required to pass the test and a practical exam on PC where the applicant solve 2 practical bioinformatics tasks.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on course enrolment limitations: omezení se vztahuje na 1 hod. cvičení v učebně COMPB, nikoli na přednášku
Listed among pre-requisites of other courses
Teacher's information
http://orion.sci.muni.cz/kgmb/bioinformat/
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2009, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2009/Bi5000