PřF:C7431 Heterocyclic Compounds - Course Information
C7431 Heterocyclic Compounds
Faculty of ScienceAutumn 2009
- Extent and Intensity
- 2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
- Teacher(s)
- prof. RNDr. Milan Potáček, CSc. (lecturer)
- Guaranteed by
- prof. RNDr. Milan Potáček, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science - Prerequisites
- Knowledge of Organic Chemistry
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- there are 11 fields of study the course is directly associated with, display
- Course objectives
- Nomenclature of heterocyclic compounds. General methods of heterocyclic compounds synthesis, cyclizations (homo and heterocyclizations), cycloadditions and ring transformations. Nonaromatic heterocyclic compounds (with stress on small rings), their reactivity and the comparison with the reactivity of analogous noncyclic compounds with heteroatoms.Aromatic heterocycles. Five membered ring heterocycles with one heteroatom and their benzo derivatives. 1,3-Azoles and 1,2-azoles. At the end of this course students should be able to name various heterocyclic compounds, to think out a method of synthesis of the given heterocycle, to recognize a diference between reactivity of the heterocyclic system aromatic and nonaromatic. Special properties of five membered heterocycles with one and two heteroatoms are summarized.
- Syllabus
- 1. Nomenclature, Hantzsch - Widman method for fused heterocycles. 2. General methods for synthesis of heterocycles (homo and heterocyclizations).3. Cycloadditions and derivatization of the heterocyclic skeleton. 4. Nonaromatical heterocyclic compounds with special respect to mall rings.5. Aromatic heterocycles: Fivemembered heterocycles with one heteroatm, structure and influence of the heteroatom upon behaviour of the system. Pyrrol, basic methods of its preparation and behaviour against electrofiles, nucleophiles and radicals. 7. Furan, basic methods of its preparation and behaviour against electrofiles, nucleophiles and radicals. Most important derivatives and thei occuarence in the nature. 8. Pyrrrol dyes. 9. Indol, chemical structure and reactivity, derivatives, indigo. Isoindol and indolisin. 10. 1.3-Azoles, their representatives and structure.Basic methods of its preparation and behaviour against electrofiles, nucleophiles and radicals. Comparison of the chemical properties with corresponding heterocycles with one heteroatom. 1.2-Azoles, their structure and representatives. Basic methods for their preparation. Chemical properties.12., 13., 14. Inovation.
- Literature
- KOVÁČ, Jaroslav, Alžbeta KRUTOŠÍKOVÁ and Rudolf KADA. Chémia heterocyklických zlúčenin. 1. vyd. Bratislava: VEDA vydavatel'stvo Slovenskej akadémie vied, 1982, 515 s. info
- JOULE, J. A., K. MILLS and G. F. SMITH. Heterocyclic chemistry [Joule, 1995]. 3rd ed. London: Chapman & Hall, 1995, 516 s. ISBN 0-412-41340-X. info
- GILCHRIST, Thomas L. Heterocyclic chemistry. 3rd ed. Essex: Longman, 1997, xvii, 414. ISBN 0582278430. info
- ČERVINKA, Otakar. Chemie organických sloučenin. Vyd. 1. Praha: Státní nakladatelství technické literatury, 1987, 1052 s. info
- Teaching methods
- lecture with a presentation of some examples
- Assessment methods
- The course is a set of lectures accompanied with solved exercises to main topics.The final examination consists of written test, which is evaluated and according with the results credits are allocated.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
- Enrolment Statistics (recent)
- Permalink: https://is.muni.cz/course/sci/autumn2009/C7431