Bi9060 Bioinformatika II - proteiny

Přírodovědecká fakulta
podzim 2011
Rozsah
1/0/0. 1 kr. (plus ukončení). Ukončení: k.
Vyučující
prof. Mgr. Jiří Damborský, Dr. (přednášející)
Mgr. et Mgr. Veronika Oškerová, Ph.D. (pomocník)
Mgr. Eva Šebestová, Ph.D. (pomocník)
Garance
prof. Mgr. Jiří Damborský, Dr.
Ústav experimentální biologie – Biologická sekce – Přírodovědecká fakulta
Kontaktní osoba: prof. Mgr. Jiří Damborský, Dr.
Rozvrh
Čt 8:00–9:50 B11/306
Předpoklady
( Bi4010 Základy molekulární biologie || Bi4020 Molekulární biologie ) && NOW( Bi5000 Bioinformatika I ) && ! C9080 Bioinformatics
Omezení zápisu do předmětu
Předmět je nabízen i studentům mimo mateřské obory.
Mateřské obory/plány
Cíle předmětu
The aim of this course is to give an introduction to Bioinformatics. Bioinformatics covers different computer applications in biological sciences and in its broadest sense the Bioinformatics means information technology applied to the management and analysis of biological data. The course will consist of theoretical part followed by practical training using computers and Internet. An introduction will be given to the theory of genome and protein information resources, to the DNA and protein sequence analysis, to the organization and searching of primary and secondary databases, etc.
Osnova
  • I. OPENING what is it Bioinformatics? study material organization lectures examination II. INTRODUCTION history of sequencing what is it Bioinformatics? sequence to structure deficit genome projects why is Bioinformatics important? patter recognition and prediction folding problem sequence analysis homo/analogy and ortho/paralogy III. INFORMATION NETWORKS what is the Internet? how do computers find each other? FTP and Telnet what is the Worl Wide Web? HTTP, HTML and URL EMBnet, EBI, NCBI SRS and ENTREZ IV. PROTEIN INFORMATION RESOURCES-I biological databases - introduction primary protein sequence databases composite protein sequence databases V. PROTEIN INFORMATION RESOURCES-II secondary databases composite secondary databases protein structure databases protein structure classification databases VI. GENOME INFORMATION RESOURCES primary DNA sequence databases specialised DNA sequence databases VII. DNA SEQUENCE ANALYSIS why to analyse DNA? gene structure gene sequence analysis expression profile, cDNA, EST EST sequences analysis VIII. PAIRWISE SEQUENCE ALIGNMENT database searching alphabets and complexity algorithms and programs sequences and sub-sequences identity and similarity dotplot local and global similarity pairwise database searching IX. MULTIPLE SEQUENCE ALIGNMENT multiple sequence alignment consensus sequence manual methods simultaneous and progressive methods databases of multiple sequence alignments hybrid approach for database searching X. SECONDARY DATABASE SEARCHING why search secondary databases? secondary databases regular expressions fingerprints blocks profiles Hidden Markov Models XI. ANALYSIS PACKAGES commercial databases commercial software comprehensive packages packages for DNA analysis intranet packages Internet packages XII. PROTEIN STRUCTURE MODELLING protein structure protein structure databases prediction of secondary structure prediction of protein fold prediction of tertiary structure modelling of protein-ligand complexes XIII. BIOINFORMATICS IN PRACTICE-I Information networks Protein information resources Genome information resources DNA sequence analysis XIV. BIOINFORMATICS IN PRACTICE-II Pairwise sequence alignment Multiple sequence alignment Secondary database searching Protein structure modelling
Literatura
  • Introduction to Bioinformatics, T.K. Attwood & D.J. Parry-Smith, Longman, Essex, 1999.
Výukové metody
lectures and class discussions
Metody hodnocení
Written test: 50 questions Oral examination: practical
Vyučovací jazyk
Angličtina
Navazující předměty
Informace učitele
http://loschmidt.chemi.muni.cz/peg/loadframe.html?courses.html
Další komentáře
Studijní materiály
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je vyučován každoročně.
Předmět je zařazen také v obdobích podzim 2010 - akreditace, podzim 2008, podzim 2009, podzim 2010, podzim 2011 - akreditace, podzim 2012, podzim 2013, podzim 2014, podzim 2015, podzim 2016, podzim 2017, podzim 2018.