Bi9410c Structural Biology - practice

Faculty of Science
Autumn 2012
Extent and Intensity
0/2/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: z (credit).
Teacher(s)
Mgr. Jan Brezovský, Ph.D. (seminar tutor)
Mgr. Eva Šebestová, Ph.D. (seminar tutor)
Guaranteed by
prof. Mgr. Jiří Damborský, Dr.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: Mgr. Jan Brezovský, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Wed 14:00–15:50 B09/316
Prerequisites
NOW( Bi9410 Structural Biology )
Knowledge on the level of basic lectures of biochemistry or molecular biology.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
Students will acquire practical understanding of freely available web servers, programs and databases applicable to the study of structure, dynamics and function of biomacromolecules, interaction of proteins with proteins, nucleic acids and small organic molecules.
Syllabus
  • 1. Structure of biomacromolecules – composition, methods for determination, application in biology, visualization.
  • 2. Databases of experimental structures – deposition, retrieval and evaluation of structures of macromolecules; selected structural databases.
  • 3. Models of structures – databases of models, methods for model quality evaluation, preparation of models.
  • 4. Prediction of structure of macromolecular complexes.
  • 5. Dynamics of macromolecules – analysis of molecular dynamics and its databases.
  • 6. Protein-protein complexes – evaluation of complex, analysis of interacions; databases.
  • 7. Protein-DNA complexes – evaluation of complex, analysis of interacions; databases.
  • 8. Protein-ligand complexes – evaluation of complex, analysis of interacions; databases.
  • 9. Analysis of protein structure – identification of important regions: binding/active sites, transport pathways, flexible regions, catalytic amino acids.
  • 10. Modification of protein structure – evaluation of effect of mutation on protein structure and function.
  • 11. Application of structural biology – biological research, drug design and development, design of biocatalyst.
Literature
  • Computational Structural Biology: Methods and Applications, T. Schwede & M. C. Peitsch, World Scientific Publishing Company, 2008
  • Structural Bioinformatics, J. Gu &P. E. Bourne, Wiley-Blackwell, 2009
  • Textbook Of Structural Biology, A. Liljas, L. Liljas, J. Piskur, G. Lindblom, P. Nissen, M. Kjeldgaard, World Scientific Publishing Company, 2009
Teaching methods
individual practice in computer lab
Assessment methods
written test
Language of instruction
Czech
Further Comments
Study Materials
Course is no more offered.
The course is also listed under the following terms Autumn 2011 - acreditation, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023.
  • Enrolment Statistics (Autumn 2012, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2012/Bi9410c