Bi7140 Molecular biology of viruses

Faculty of Science
autumn 2021
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Vladislava Růžičková, CSc. (lecturer)
Mgr. Tibor Botka, Ph.D. (lecturer)
Guaranteed by
doc. RNDr. Vladislava Růžičková, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Vladislava Růžičková, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Thu 10:00–11:50 B11/306
Prerequisites
B4030 Molecular biology || B5740 Molecular biology || B6130 Molecular biology || B7940 Molecular biology || B4020 Molecular biology || Bi4010 Essential molecular biology || Bi4020 Molecular biology
1.Molecular structure reproduction a function of procaryotic and eucaryotic genome. 2. Basic methods in molecular biology 3. Molecular foundation of acquired immunity. Molecular foundation of cancerogenesis.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 90 student(s).
Current registration and enrolment status: enrolled: 1/90, only registered: 0/90, only registered with preference (fields directly associated with the programme): 0/90
fields of study / plans the course is directly associated with
there are 11 fields of study the course is directly associated with, display
Course objectives
At the end of the course students should be able to distinguish and explain principles of the molecular biology, pathology and evolution of bacterial viruses, animal and plant viruses.
Learning outcomes
Student will be able to:
- explain the main molecular biological properties of bacterial viruses;
- explain the main molecular biological properties of animal and giant viruses;
- explain the main molecular biological properties of plant viruses;
- describe the molecular basis of cellular parasitism of viruses;
- compare and highlight differences in the process of reproduction of different types of viruses;
- to analyze current scientific knowledges in the field of virology;
- write an article on the importance of viruses in medical practice;
Syllabus
  • Subject Molecular biology of viruses contains theory of molecular genetics of bacterial phages and eukaryotic viruses. Morphology and structure of phages, infection and lysis of bacterial cells caused by phage virions, adsorption of phage virion to the surface of bacterial cells, synthesis of bacterial viruses in host cell, mutation and recombination of bacteriophage, lysogens and genetics of temperate phage, general characteristics of some temperate phages are included in part of procaryotic viruses. Molecular biology and genetics of vertebrate and invertebrate viruses concern the papovaviruses, adenoviruses, herpesviruses, poxviruses, parvoviruses, reoviruses, flaviviruses, picornaviruses, togaviruses, arteriviruses, rhabdoviruses, paramyxoviruses, filoviruses, orthomyxoviruses, bunyaviruses, retroviruses, hepadnaviruses. Molecular biology of retroviruses including the virus HIV and HTLV, adenoviruses, herpesviruses, influenzavirus, hepadnaviruses and oncoviruses are given in detail. Molecular biology and genetics of plant viruses is focused on the caulimoviruses, geminiviruses, bromoviruses, nepoviruses, tymoviruses, tobamoviruses, tombusviruses, luteoviruses, hordeiviruses, potexviruses etc. Characteristics of main types of plant diseases caused by viruses are explained. Molecular taxonomy, evolution of viruses, prions and viroids are also declaimed. After graduation this course, the student should be able to differentiate the molecular basis of viral vitality and evolution.1. Molecular characterisation of live noncellular systems, terms and definition explaining the nature molecular biology of viruses 2. Properties of viruses having importance in their molecular classification 3. Life cycle of viruses and the types of viral infections in host organisms, molecular mechanisms of viral persistence and latency 4. Molecular characteristic of viruses of procaryotes 5. Molecular characteristic of viruses of eucaryotes i.e. vertebrates, invertebrates, and plants. 6. Molecular characteristic of oncoviruses 7. Molecular basis of occurrence of transmissible encephalopathy (TSE) 8. Molecular diagnostics and evolution of viruses.
Literature
    recommended literature
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Translated by Jiřina Relichová. Druhé, aktualizované vydá. Brno: Masarykova univerzita, 2017, xix, 844. ISBN 9788021086135. info
  • ROSYPAL, Stanislav. Úvod do molekulární biologie. Třetí inovované vydání. Brno, 2000, 300 pp. Díl III. Molekulární biologie virů. ISBN 80-902562-2-8. URL info
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Karel PETRZIK and Vladislava RŮŽIČKOVÁ. Úvod do molekulární biologie IV. Molekulární biologie rostlinných virů, Priony, Molekulkární evoluce, Vznik života, Metody molekulární biologie, Genové inženýrství (Introduction to molecular biology IV.). Třetí inovované vydání. Brno: Rosypal S., Grafex, 2002, 300 pp. Díl čtvrtý. ISBN 80-902562-4-4. info
  • Racaniello, V.R., Rall, G.F. (2020). Principles of Virology, Volume 1. American Society for Microbiology.608. ISBN 9781683672845.
  • CARTER, John B. and Venetia A. SAUNDERS. Virology : principles and applications. 2nd ed. Chichester: Wiley, 2013, xxix, 364. ISBN 9781119991434. info
  • FLINT, S. Jane. Principles of virology. 3rd ed. Washington, DC: ASM Press, 2009, xxii, 569. ISBN 9781555814793. info
Teaching methods
Lecture is attended by commentated PowerPoint presentations including schemes, diagrams, figures and animated illustrations concerning the topic of the lecture. Study materials are available in the IS.
Assessment methods
Lecture is finished by written examination including: test questions, making graphics with commentary and answer the single questions. Graduation of this subject depends on minimally 60% successfulness in written examination and attending on lectures.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
Teacher's information
http://orion.sci.muni.cz/kgmb/Student/7140.htm
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (autumn 2021, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2021/Bi7140