PřF:Bi0580 Developmetal Genetics - Course Information
Bi0580 Developmetal Genetics
Faculty of ScienceAutumn 2023
- Extent and Intensity
- 2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
- Teacher(s)
- prof. RNDr. Boris Vyskot, DrSc. (lecturer)
Ing. Vojtěch Hudzieczek, Ph.D. (lecturer)
Ing. Václav Bačovský, Ph.D. (lecturer)
Mgr. Ivana Kupčíková, DiS. (assistant) - Guaranteed by
- prof. RNDr. Boris Vyskot, DrSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Boris Vyskot, DrSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science - Timetable
- Tue 15:00–16:50 E25/209
- Prerequisites
- (SOUHLAS || Ex_3162 Obecná genetika || Imp_9126 Obecná genetika || B1900 Basic genetics || BMB32 Basic genetics || B6730 Basic genetics || B8470 Genetics || B3060 Basic genetics || Bi3060 Basic genetics ) && ( Ex_3065 Molekulární biologie || Imp_9115 Molekulární biologie || B3120 Molecular and cell biology || B4020 Molecular biology || B5740 Molecular biology || B6130 Molecular biology || B7940 Molecular biology || Bi4010 Essential molecular biology || Bi4020 Molecular biology ) && ( Bi6401 Bc Thesis II || Bi3002 Bc thesis EMB 2 || Bi6491 Bachelor Thesis LGMD II || SOUHLAS)
Foreign students are welcome (relevant literature in English is available). - Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Bioanalytical Laboratory Diagnostics in Medicine - Medical Genetics and Molecular Diagnostics (programme PřF, N-LGM)
- Biochemistry (programme PřF, N-CH)
- Human Biology (programme PřF, N-BCL)
- Medical Genetics and Molecular Diagnostics (programme PřF, N-BI)
- Molecular Biology and Genetics (programme PřF, N-BI, specialization Genomika a proteomika)
- Molecular Biology and Genetics (programme PřF, N-BI, specialization Molekularni a geneticka diagnostika)
- Molecular Biology and Genetics (programme PřF, N-EXB, specialization Antropogenetika)
- Molecular Biology and Genetics (programme PřF, N-EXB, specialization Molekulární biologie a genetika)
- Molecular Biology and Genetics (programme PřF, N-MBG)
- General Biology (programme PřF, N-BI, specialization Ekotoxikologie)
- General Biology (programme PřF, N-BI, specialization Plant Physiology)
- General Biology (programme PřF, N-BI, specialization Physiology of Animals)
- Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)
- Special Biology (programme PřF, N-EXB, specialization Experimentální biologie rostlin)
- Special Biology (programme PřF, N-EXB, specialization Experimentální biologie živočichů a imunologie)
- Developmental Biology (programme PřF, N-EBZ)
- Course objectives
- At the end of this course, students should be able to understand common features of developmental processes in phylogenetically distant groups of organisms, genetic and epigenetic fundamentals of developmental processes on molecular level.
- Learning outcomes
- At the end of this course, students should be able to understand common features of developmental processes in phylogenetically distant groups of organisms, genetic and epigenetic fundamentals of developmental processes on molecular level.
- Syllabus
- (1) General principles of developmental genetics, history, embryonic induction (Spemann), models of flags (Wolpert), reaction-diffuse model of development (Turing), regulative and mosaic development, homeosis (Bateson, Goethe), programmed cell death, preformism and epigenesis (Aristotle), germ-line (Weismann), genes with maternal effects, morphallaxis and epimorphosis
- (2) Developmental and epigenetic processes in bacteria (Bacillus subtilis), fungi (yeast, Dictyostelium) and primitive animal models (Paramecium, Hydra, Caenorhabditis)
- (3) Flatworms – rediscovered model of developmental biology: regeneration, neurobiology, allometry, RNA-interference
- (4) Drosophila melanogaster – the queen of developmental genetics: genetic control cascade of embryogenesis, maternal and zygotic genes, homeotic genes, colinearity, imaginal discs, homeotic transdetermination
- (5) Deuterostomia as important models for developmental studies: sea urchin, fish, amphibians, birds, mammals
- (6) Medical aspects of developmental biology: therapy of infertility, malformations, teratogenesis, candidate genes, positional cloning, stem cells, DNA therapy, epigenetic diseases
- (7) Alternative models of plant developmental genetics: Anabaena, Acetabularia, Chlamydomonas, Volvox, Fucus, Marchantia, Physcomitrella, Ceratopteris, Populus, Antirrhinum, Linaria, Linum, Craterostigma, Zinnia, Silene, Zea, Oryza, Brachypodium, Gagea, Eleocharis, orchids
- (8) Arabidopsis thaliana model: gametophyte and sporophyte, imprinting in endosperm, control of embryogenesis, regulative development, control of flowering, MADS-box genes, homeobox genes, Polycomb proteins (Medea), paramutations, epimutations
- (9) Sex and its determination, genetically, hormone and epigenetically controlled sexuality, structure and evolution of sex chromosomes, gynandromorphy, dioecy, X- and Y-linked inheritance, molecular mechanisms of sex determination
- (10) Principles of epigenetic inheritance, mechanisms of epigenetic processes, evolutionary and developmental processes (or evo/devo): heterotopic changes, heterochronic changes, environmental adaptation
- Literature
- required literature
- VYSKOT, Boris. Epigenetika. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2010, 150 s. ISBN 9788024425344. info
- VYSKOT, Boris. Přehled vývojové biologie a genetiky. Praha: Ústav molekulární genetiky AV ČR, 1999, 241 s. ISBN 80-902588-1-6. info
- recommended literature
- Principles of developmental genetics. Edited by Sally A. Moody. Boston: Elsevier Academic Press, 2007, xiv, 1055. ISBN 9780123695482. info
- Teaching methods
- Lectures are based on power-point pictures, tables and texts elaborated according to textbooks, monographs and scientific papers which are explained and complemented with live commentaries.
- Assessment methods
- Oral examination follows the written test in which students should answer 50 questions covering main topics of the lecture. During the oral examinations the students have to prove their knowledge on particular examples. To pass the exam they should answer 70% of the answers.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually. - Teacher's information
- http://www.ibp.cz/labs/PDG/
- Enrolment Statistics (Autumn 2023, recent)
- Permalink: https://is.muni.cz/course/sci/autumn2023/Bi0580