PřF:BA480 Quantitative structure - activ

BA480 Quantitative structure - activity relationships

Faculty of Science
Spring 2000

Extent and Intensity

2/0/0. 2 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. Ing. Bohuslav Rittich, CSc. (lecturer)

Guaranteed by

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

Syllabus

Biological activity of compounds and the methods of their measurements. Cell membrane structure. Membrane transport of polar and nonpolar molecules. Physico-chemical properties of compounds and their parametrisation. Hydrophobic parameters. Relative hydrophobicity of compounds. Parametrisation of the electronic and steric effects of molecules. Noncovalent interactions and their importance in biological systems. Quantitative structure-activity relationships. Hansch approach. Free-Wilson approach. Indicator variables. Regression analysis and its problems. Strategy in the statistical evaluation of real data sets. Design of biologically active molecules. Examples of evaluation of the antimicrobial activity of selected compounds. Other methods used in quantitative structure-activity relationships.

Literature

3. Exner O. Correlation Analysis of Chemical Data. Plenum Press and SNTL. Prague 1988.
1. Kuchař M., Rejholec V. Využití kvantitativních vztahů mezi strukturou a biologickou aktivitou. Academia. Praha 1987. 2. Kotyk A. Struktura a funkce biomembrán. Skripta MU v Brně. Brno 1996.

Language of instruction

Czech

Further Comments

The course is taught annually.
The course is taught: every week.

The course is also listed under the following terms Spring 2001, Spring 2002.