C8850 Structure and Function of Biomembranes

Faculty of Science
Spring 2003
Extent and Intensity
3/0/0. 3 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Arnošt Kotyk, DrSc. (lecturer)
prof. RNDr. Vladimír Mikeš, CSc. (lecturer)
Guaranteed by
prof. RNDr. Arnošt Kotyk, DrSc.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Arnošt Kotyk, DrSc.
Prerequisites
C4182 Biochemistry II || C3580 Biochemistry || C6030 Biochemistry II
Basic knowledge of biochemistry
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 25 fields of study the course is directly associated with, display
Course objectives
Basic components of membranes, their synthesis. Membrane functions, transport, energy transduction and transformation, flux of information signals. Structure and function of mitochondrial membrane. Physical and chemical signals, neurochemistry.
Syllabus
  • 1. Four principles of structural and functional organization of a cell: (a) chromosomes and ribosomnes; (b) membranes; (c) cytoskeleton; (4) cell envelope. 2. Components of cell membranes, their hierarchical organization. Lipids and proteins, sugar components. Movement of membrane components. Physico-chemical basis of interac-tions within membranes and between membranes. 3. Synthesis and composition of membrane lipids and proteins, their movement to their destination in the cell. 4. Three categories of membrane functions: flow of matter, flow of energy and flow of information. 5. Physico-chemical principles of movement across membranes, its kinetics and ener-getics. 6. Nonspecific permeation of substances. Dissolving in lipids and movement through permanent and transient pores. 7. Theory of specific transport. Examples of movement through channels, on trans-porters and by group translocation. Endocytosis and exocytosis. 8. Conversions of energy in membranes. Physical reactions of photosynthesis. Struc-ture of chloroplasts, light-harvesting complexes, photosynthetic reaction centres. 9. Structure and function of mitochondria. Formation of gradient of electrical potential and of pH. Synthesis of ATP. 10. Conversions of mechanical and electrical energy. 11. Flow of information signals across membranes. Molecular basis of their trans-duction. 12. Physical signals and their processing vision, hearing, touch, perception of temperature, of magnetic and electric field. 13. External chemical signals smell, taste; bacterial chemotaxis. 14. Internal chemical signals. Principles of neurochemistry, effects of hormones and cytokines. Principles of imunochemistry.
Literature
  • KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
  • ALBERTS, Bruce. Essential cell biology : an introduction to the molecular biology of the cell. New York: Garland Publishing, 1998, xxii, 630. ISBN 0-8153-2045-0. info
Assessment methods (in Czech)
Výběrová přednáška, zkouška nebo kolokvium
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Spring 2000, Spring 2001, Spring 2002.
  • Enrolment Statistics (recent)
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