Bi6930 Immunotoxicology

Faculty of Science
Spring 2004
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Luděk Bláha, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Luděk Bláha, Ph.D.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Luděk Bláha, Ph.D.
Timetable
Tue 7:00–8:50 kamenice
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Immunotoxicology - research branch studying effects of stressors (mainly chemical compounds) on immune system and the importance of immune system changes for organism health.. Immune system - components, function, communication. Experimental design in immunotoxicology. Tiered approach. Laboratory methods in immunotoxicology. Factors affecting immune system. Special immunotoxicology - drugs, pollutants. Ecological immunotoxicology - invertebrates, fish, amphibians. Risk assessment in immunotoxicology.
Syllabus
  • 1. Immunotoxicology. Introduction, history, aims and scopes, human immunotoxicology, ecological immunotoxicology. 2. Immune system. Components of immune system, function, communication, immune system as a target of xenobiotics. Immune system as a part of an organism - interactions, controls, homeostasis, (xeno-)estrogens. 3. Experimental design in immunotoxicology. Exposure, response. "Tier I" and "Tier II" methods. Animal models in immunotoxicology, batteries of immunotoxicology tests. 4. Laboratory methods in immunotoxicology. Assays of immunocompetence, macrophage function assays, host resistance, antitumor immunity, hypersensitivity, autoimmunity. 5. Special immunotoxicology 1 - introduction. Factors affecting immune system (climate, geography, biorhythms, stress, social habits, chemicals, irradiation and other physico-chemical factors). 6. Special immunotoxicology 2 - immunotoxicology of drugs (antibiotics, important pharamceuticals, immunosuppressives a immunomodulators, antitumor therapy). 7. Special immunotoxicology 3 - immunotoxicology of pollutants (metals, pesticides, industrial chemicals - PCBs, PAHs, PCDD(F)s, other organic pollutants, azbestosis, silikosis). 8. Ecological immunotoxicology. Animal immune system and interactions with xenobiotics. Invertebrates, fish, amphibians, birds, mammals. Markers of immune system alterations, ecological consequences. Case studies. 9. Risk assessment. Immunotoxicology as a branch of general toxicology, hazard identification, uncertainities.
Literature
  • Immunotoxicology and immunopharmacology. Edited by Jack H. Dean. 2nd ed. New York: Raven Press, 1994, xxi, 761 s. ISBN 0-7817-0219-4. info
  • Wagner, V., Wagnerová, M. Ekoimunologie, Avicenum, 1988, Praha
  • Ferenčík, M. Immunochémia, Alfa, 1989, Bratislava
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2016.
  • Enrolment Statistics (Spring 2004, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2004/Bi6930