Bi8110 Genotoxicity and cancerogenesis

Faculty of Science
Spring 2004
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer), doc. RNDr. Martin Vácha, Ph.D. (deputy)
Guaranteed by
prof. RNDr. Jiřina Hofmanová, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Jiřina Hofmanová, CSc.
Timetable
Tue 13:00–14:50 BFU
Prerequisites
Passing through lecture of Physiology of cell systems is neccessary
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 6 fields of study the course is directly associated with, display
Course objectives
Course gives a complex view of the process of carcinogenesis, including both mutagenic (genotoxic) and epigenetic (non-genotoxic) factors that play a role during the development of cancer. It is focused on principles leading to disruptions in signal transduction inside a cell and cell cycle deregulation of the cell cycle, proliferation, differentiation and apoptosis. Furthermore, it gives an overview of the role of intercellular communications within a tissue (disorders of homeostasis) and the role of environmental factors, such as diet (especially lipid components). Attention is also paid to problems of cancer prevention, diagnosis and therapy, to present methods of detection of carcinogenic potential of environmental polutants and their profit in experimental ecotoxicology.
Syllabus
  • 1. Genetic and epigenetic aspects of carcinogenesis. Process of carcinogenesis Tumor classification The stages of carcinogenesis Mutagenesis Initiation Promotion Progression 2. Modulations of signal transduction. Oncogenes and tumor supressor genes Changes in regulation of cytokinetics e. g. cell cycle, proliferation, differentiation and apoptosis Perturbation of homeostasis Inter- and intracellular communication Adhesion Immortalization Metastases Angiogenesis 3. Disorders in differentiation Pathological effects of cytokines 4. Origin of specific types of tumors (leukemias, breast, colon, liver, skin cancer) 5. Prevention, diagnosis and tumor therapy 6. Predictive oncology Prognostic vs. predictive factors Data management 7. The role of environmental factors in carcinogenesis Genotoxic vs. epigenetic effects 8. Nutrition aspects of carcinogenesis 9. Current system of detection of carcinogenic properties of risk substances Prospectives of experimental ecotoxicology
Literature
  • What you need to know about cancer, Scientific American - Special Issue, September 1996
  • FREMUTH, František. Regulace a inhibice růstu normálních a nádorových buněk. 1. vyd. Praha: Státní pedagogické nakladatelství, 1986, 223 s. info
  • J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
  • V. Wagner, M. Wagnerová: Ekoimunologie, Avicenum, Praha 1988
  • ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
  • P. Klener: Chemoterapie v komplexní léčbě zhoubných nádorů a hemoblastóz, Avicenum, Praha 1987
  • Hemopoietic growth factors, oncogenes and cytokines in clinical hematology (Eds. E. Cacciola, A. B. Deisseroth, R. Giustolisi), Karger1994
  • The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 199
  • J. Hofmanová, A. Kozubík: Apoptóza a nádorová onemocnění - Přehled, Klinická onkologie 8, 5, 1995.
  • A. Kozubík, J. Hofmanová: Hodnocení účinků negenotoxicky působících polutantů. Sborník konference ERA 97, Hodnocení rizik pro životní prostředí, Brno 1997, str. 220-225.
  • A. Kozubík, J. Hofmanová: Význam nenasycených mastných kyselin v rozvoji a chemoprofylaxi nádorů kolorekta - Přehled, Klinická onkologie 1999
  • + doporučené speciální separáty a schemata z přednášek
Language of instruction
Czech
Follow-Up Courses
Further Comments
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2004, recent)
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