IC004 Combinatorial Chemistry and High-throughput Synthesis

Faculty of Science
Spring 2006
Extent and Intensity
0/0. 1 credit(s). Type of Completion: z (credit).
Guaranteed by
prof. RNDr. Petr Klán, Ph.D.
Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Petr Klán, Ph.D.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
Prof. Oliver Kappe (Institute of Chemistry, Karl-Franzens-University Graz, Austria) This special course provides the attendees with an introduction into the field of combinatorial chemistry and high-throughput synthesis as practiced in many academic and industrial research laboratories today. The focus will be on understanding the basic concepts of classical combinatorial chemistry principles and solid-phase synthesis, but also providing education about more modern techniques, such as the use of polymer-supported reagents/scavengers, fluorous synthesis and other high-throughput synthetic technologies. The course is desined for advanced undergraduate and graduate students.
Syllabus
  • PART I: Introduction to Combinatorial Principles PART II: Solid Phase Organic Synthesis Supports (Base Polymers) Linkers and Cleavage Conditions Analysis and Reaction Monitoring PART III: Solution Phase Combinatorial Synthesis Synthesis on Soluble Supports Fluorous Phase Strategies Polymer-Supported Reagents and Scavengers PART IV: Combinatorial Technologies Combinatorial Technologies Deconvolution Strategies Encoding and Decoding PART V: Automation and Robotics SPOS with Lanterns (Mimotopes) Directed Sorting (IRORI) Automation in Synthesis and Purification
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught only once.
The course is taught: in blocks.
Note related to how often the course is taught: termín: 10.-11.4.2006.
General note: přednášející: prof. Oliver Kappe (Karl-Franzens-University, Graz, Austria).
Teacher's information
http://www.uni-graz.at/~kappeco/
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