Bi6726 Physiology of pharmaceuticals and toxic compounds

Faculty of Science
Spring 2010
Extent and Intensity
2/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer), prof. RNDr. Alois Kozubík, CSc. (deputy)
RNDr. Miroslav Machala, CSc. (lecturer), prof. RNDr. Alois Kozubík, CSc. (deputy)
Guaranteed by
prof. RNDr. Jan Vondráček, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Thu 9:00–10:50 BFU
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
At the end of the course students should be able to understand the principles of modulations of physiological processes in organism by xenobiotics. They should be able to make deductions based on the acquired knowledge in xenobiochemistry, toxicology and pharmacology, in order to interpret physiological mechanims underlying the effects of toxic compounds and pharmaceuticals within organisms. At the end of this course, students should have a basic understanding of metabolism of xenobiotics within organism including the effects of xenobiotics at both cellular and organismal levels, impact of xenobiotics on endocrine regulation and development and basic types of toxic effects of xenobiotics.
Syllabus
  • 1)An overview of chemical compounds that may disrupt normal physiological functions - anthropogenic organic pollutants, pharmaceuticals, secondary metabolites (dietary compounds and toxins); main exposure routes.
  • 2)Basic principles of metabolization, transport and accmulation of xenobiotics within body, Phase I and II biotransformation enzymes; antioxidants;Phase III. proteins.
  • 3)Basic types of toxicity of xenobiotics (genotoxicity, hepatotoxicity, neurotoxicity, immunotoxicity, tumor promotion, endocrine disruption).
  • 4)Basic classes of pharmaceuticals, pharmacokinetics, toxic side-effects of pharmaceuticals; cytostatics, hormones, neuroleptic compounds.
  • 5)Deregulation of signal transduction by xenobiotics.
  • 6)bHLH/PAS protein family; HIF-1alpha, Ah receptor and its pathway; toxic effects of AhR ligands.
  • 7)Nuclear receptors (ER, AR, PR, GR, TR, RAR/RXR, CAR, PXR, PPAR) their ligands; their role in regulation of metabolism; physiological functions based on modulation of target gene expression.
  • 8)Biosynthesis and metabolism of endogenous NR ligands (steroids, fatty acids, lipid mediators); hormonal regulation of biosynthesis.
  • 9)Principles of hormonal regulation and endocrine disruption in invertebrates.
  • 10)Endocrine regulation and disruption in vertebrates: ER, AR, PR, GR.
  • 11)Endocrine disruption and regulation of embryonal and post-natal development of vertebrates: RAR, RXR, PPAR, TR.
  • 12)Natural compounds; sources and chemoprotectivity.
Literature
  • Vanden Heuvel et al.: Cellular and Molecular Toxicology, Comprehensive Toxicologyu Vol. 14, Elsevier, 2002
  • Norris, D.O.: Vertebrate Endocrinology, 4th ed., Elsevier, 2007
  • Josephy P.D. et Mannervik B.: Molecular Toxicology, 2nd ed., OUP, 2006
Teaching methods
lectures
Assessment methods
Written test (approximately 10 questions; 45 min).
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2010, recent)
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