Bi5045 Biostatistics for Computational Biology

Faculty of Science
Spring 2011 - only for the accreditation
Extent and Intensity
3/1/0. 4 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
RNDr. Tomáš Pavlík, Ph.D. (lecturer)
prof. RNDr. Ladislav Dušek, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Ladislav Dušek, Ph.D.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.
Prerequisites
None - it is a basic course.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 6 fields of study the course is directly associated with, display
Course objectives
The aim of this course is to introduce the students to the field of biostatistics, its principles and methodology, and to teach them how to analyze data regarding real biological and clinical problems.
At the end of the course students should be able to:
1. formulate statistical hypothesis according to given type of data;
2. design and optimalize biological and clinical experiments;
3. apply analytical methods and verify correctness of their use;
4. understand statistical terminology and read scientific papers;
5. properly interpret their own results;
6. critically assess published results.
Syllabus
  • 1. Introduction to biostatistics. Examples of problems addressed with biostatistical methods.
  • 2. Mutual relationship among probability theory, statistics and biostatistics.
  • 3. Data types, their description and visualization.
  • 4. Random variable, probability distributions and its characteristics, real data.
  • 5. Introduction to estimation theory. The principles and criteria for deriving statistical estimates.
  • 6. Various estimators of parameters of random variables.
  • 7. Introduction to hypotheses testing. Logic of hypotheses testing and related terms.
  • 8. Parametric and nonparametric testing of hypotheses regarding quantitative random variables.
  • 9. Analysis of variance (ANOVA).
  • 10. Testing hypotheses with binary and categorical random variables. Goodness of fit tests.
  • 11. Experimental design. Required sample size determination for hypothesis tests.
  • 12. Correlation and regression analysis. Correlation and causality. Linear regression model.
  • 13. Introduction to stochastic modelling. Model and its components.
  • 14. Introduction to survival analysis. Censoring principle. Parametric and nonparametric survival function estimates.
Literature
  • Zar, J.H. (1998) Biostatistical analysis. Prentice Hall, London. 4th ed.
  • Sokal, R.R., Rohlf, F.J. (1994) Biometry, W. H. Freeman, 3th ed.
  • ALTMAN, Douglas G. Practical statistics for medical research. 1st ed. Boca Raton: Chapmann & Hall/CRC, 1991, xii, 611. ISBN 0412276305. info
Teaching methods
Students are encouraged to actively participate on the discussed issues as well as they are encouraged to ask questions and comment on examples. The lectures are accompanied with one hour practices focused on computational aspects of key problems and methods of biostatistics.
Student attendance is expected.
Assessment methods
This course is finished by written exam aimed on principles and correct application of methods for solving of practical examples.
There are two short tests during the semester that are included in the final evaluation.
Language of instruction
Czech
Follow-Up Courses
Further Comments
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses
Teacher's information
http://www.cba.muni.cz/vyuka/
The course is also listed under the following terms Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020.