PřF:Bi5595 Basics in Toxicology - Course Information

Bi5595 Basics in Toxicology

Extent and Intensity

2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium), z (credit).

Teacher(s)

doc. Mgr. Klára Hilscherová, Ph.D. (lecturer)
Mgr. Ondřej Adamovský, Ph.D. (lecturer)
Mgr. Jiří Novák, Ph.D. (lecturer)
Sergio Jarque Ortiz, Ph.D. (lecturer)
prof. RNDr. Luděk Bláha, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Ivan Holoubek, CSc.
RECETOX – Faculty of Science
Contact Person: doc. Mgr. Klára Hilscherová, Ph.D.
Supplier department: RECETOX – Faculty of Science

Timetable

Mon 13:00–14:50 D29/252-RCX1

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to:
- clarify principles and methods of molecular toxicology;
- discuss causes of organ and organismal toxicity in human;
- explain basic approaches and principles of ecotoxicology;
- critically assess exposure sources (industrial and professional exposure and toxicity), etc.;
- describe the biotransformation and toxicokinetics of xenobiotics;
- characterize the major phases of interaction of xenobiotics with organism, including the dose-response relationship;
- understand the issues related to mutagenesis and carcinogenesis;
- summarize methods in experimental toxicology, know modern methods in toxicology and their development;
- have the general knowledge in the main fields associated with toxicology;
- be well oriented in the area of clinical toxicology; epidemiology, immunotoxicology, reproductive toxicology; - be well oriented in toxicology literature and actively use international toxicology databases;
- discuss and critically evaluate toxicological issues of main types of inorganic and organic compounds (pharmaceuticals, priority pollutants, metals etc.);
- define toxicological problems of agrochemicals, namely pesticides;
- know the rules for protection and first aid in case of poisoning by basic types of chemicals;

Syllabus

• 1. Introduction to Toxicology – About the Class, What is Toxicology, Historical Aspects, Basic Concepts in Toxicology, Branches of Toxicology
• 2. General Toxicology – Principles of Toxicology, Mechanisms of Toxicity, Types of Responses, Types of Toxic Substances, Types of Exposure, Dose–response Relationship,
• 3. Disposition of Toxicants – Uptake/Absorption, Distribution, Metabolism, Excretion of toxicants, Biotransformation of Xenobiotics, Toxicokinetics, Variations in Response in Different Animal Species
• 4. Non-organ Toxicology – Mutagenesis and Carcinogenesis, Genetic Toxicology, Cell Toxicology, Molecular Toxicology, Toxicogenomics
• 5. Organ Toxicology I. – Immune System, Liver, Kidney, Respiratory System, Heart and Vascular System, Skin
• 6. Organ Toxicology II. – Nervous System, Reproductive System, Endocrine System
• 7. Toxic Agents I. – Pesticides, Metals, Solvent and Vapors, Organic pollutants, Radiation and Radioactive Materials
• 8. Toxic Agents II. – Household Chemicals, Pharmaceuticals, Animal Venoms, Plants
• 9. Environmental Toxicology – Environmental Pollution and its Effects, Ecotoxicology
• 10. Toxicity Analysis, Evaluation and Diagnosis, Treatment, Experimental Methods in Toxicology
• 11. Regulatory Toxicology, Environmental Epidemiology and Human Risk Assessment, Risk Communication
• 12. Applications of Toxicology – Food Toxicology, Analytic/Forensic Toxicology, Clinical Toxicology, Occupational Toxicology
• 13. Practical Aspects of Toxicology, Rules for Protection and First Aid in Case of Poisoning by Basic Types of Chemicals;

Literature

• Casarett & Doull's essentials of toxicology. Edited by Curtis D. Klaassen - John B. Watkins. 2nd ed. New York: McGraw-Hill Medical, 2010, xi, 459. ISBN 9780071742740. info
• Principles and methods of toxicology. Edited by A. Wallace Hayes. 5th ed. New York: Informa Healthcare, 2008, xxiii, 227. ISBN 9780849337789. info
• BOELSTERLI, Urs A. Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets. London: Taylor & Francis, 2003, xxiv, 314. ISBN 0-415-28458-9. info
• TICHÝ, Miloň. Toxikologie pro chemiky : toxikologie obecná, speciální, analytická a legislativa. 2. vyd. Praha: Karolinum, 2003, 119 s. ISBN 802460566X. info
• PROKEŠ, Jaroslav. Základy toxikologie. 1. vyd. Praha: Karolinum, 1997, 165 s. ISBN 8071844187. info

Teaching methods

The lectures are interactive with support of audiovisual presentations. Students are encouraged to get involved in discussion on the presented topics to support their critical thinking. The emphasis is placed on toxicology mechanisms and principles and broader context and practical applications of the individual toxicology branches for protection of health and the environment. Part of the class is also a seminar project based on a study and synthesis of information on a specific topic.

Assessment methods

The attendance to the lectures is highly recommended for successful fulfillment of the class´ aims and also in regard to the interactive style of the lectures. There will be one written test during the semester to check the gained knowledge. Part of the class is also a seminar project. The final evaluation will be based on a final written test at the end of semester.

Language of instruction

Czech

Further Comments

Study Materials
The course is taught annually.

• Enrolment Statistics (Spring 2014, recent)
  
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