Bi5180 Quantitative genetics

Faculty of Science
Spring 2019
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Tomáš Urban, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Renata Veselská, Ph.D., M.Sc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. Ing. Tomáš Urban, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Mon 18. 2. to Fri 17. 5. Wed 16:00–17:50 B11/333
Prerequisites
Bi3060 Basic genetics && Bi5040 Biostatistics - basic course
Basic knowledge of genetics and statistics.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to understand and explain genetics quantitative traits, nature of inheritance of quantitative traits, the genetic mechanisms at the population level, and assess their genetic variability. ;
Students will get an overview and practical skills in the estimation of genetic parameters, in particular, heritability, and their practical use in breeding - estimation of breeding value. ;
Interpret these findings and use them as a basis for targeted improvement of livestock. ;
Link knowledge of classical quantitative genetics with molecular genetics approaches in modern breeding techniques - MAS and genomic selection.
Syllabus
  • Importance of quantitative genetics
  • Phenotypic diversity and genetic variation - a description of the genetic structure of populations - the concept H.-W.
  • Effect of selection and mutation on the genetic structure of populations.
  • Effect of migration, genetic drift on population genetic structure
  • Effect of inbreeding on the genetic structure of populations
  • Fundamentals of quantitative genetics - continuous variation and quantitative traits, ANOVA
  • Genetic parameters, their properties and estimations - genetic variance, coefficient of heritability and repeatability, genetic correlation and correlated properties
  • Linear models for estimation of genetic parameters, BLUP - Animal Model
  • Quantitative genetics in breeding - principles and practices
  • Genetic aspects of estimation of breeding values
  • Genetic markers and QTL - QTL mapping
  • Basic principles of application of genetic markers - MAS, MAI, genomic selection
Literature
    recommended literature
  • Urban T. (2008) Virtuální svět genetiky 3 - principy genetiky populací a kvantitativních znaků. [online] MENDELU, URL
Teaching methods
Lectures, class discussion, homeworks
Assessment methods
essay, oral exam
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2019, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2019/Bi5180