PřF:F8390 Metalloproteins - Course Information
F8390 Metalloproteins: structure and function
Faculty of ScienceSpring 2024
- Extent and Intensity
- 1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: k (colloquium).
- Teacher(s)
- prof. Dr. Jiří Kozelka, PhD. (lecturer)
- Guaranteed by
- doc. Mgr. Karel Kubíček, PhD.
Department of Condensed Matter Physics – Physics Section – Faculty of Science
Contact Person: prof. Dr. Jiří Kozelka, PhD.
Supplier department: Department of Condensed Matter Physics – Physics Section – Faculty of Science - Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Biophysics (programme PřF, M-FY)
- Biophysics (programme PřF, N-FY, specialization Molekulární biofyzika)
- Course objectives
- The main objective of the course is to provide the students with the ability to
- name the occurrence of transition metal complexes inside metalloproteins
- disscuss how inorganic chemists model the active sites of metalloproteins
- apply diverse spectroscopic methods in the study of metal active sites of metalloproteins
- disscuss examples of how nature uses the same active site for different purposes and also the mechanisms of the principal oxygen carriers the nature developed. - Learning outcomes
- After passing the course, the students should be able to
- name and describe metal complexes inside metalloproteins
- disscuss how the models of active sites of metalloproteins
- apply spectroscopic methods in the study of metal active sites of metalloproteins - Syllabus
- 1. Introduction
- 1.1. Metal ions: Functions in Biological Chemistry
- 1.2. Some fundamental metal sites in metalloproteins
- 2. Metalloproteins reacting with oxygen
- 2.1. General considerations
- 2.2. Oxygen transport proteins & Oxygenases
- 2.2.1. Hemoglobin, Myoglobin & Cytochrome P450
- Insert: Introduction to inorganic spectroscopy
- Insert: Important ligands in metalloproteins
- 2.2.2. Hemocyanin & Tyrosinase
- 2.2.3. Hemerythrin & Ribonucleotide reductase & Methane monooxygenase diiron subunits
- 3. Examples of other active sites in metalloproteins
- Literature
- LIPPARD, Stephen J. and Jeremy M. BERG. Principles of bioinorganic chemistry. Mill Valley: University Science Books, 1994, 411 s. ISBN 0-935702-73-3. info
- Teaching methods
- lectures, class discussion,
- Assessment methods
- 1 Mid-term written test
(not obligatory but highly recommended since it will give an impression of final test)
1 Final written test
A satisfactory accomplishment of the test will be required for the 2 credits given for this course. - Language of instruction
- English
- Further comments (probably available only in Czech)
- The course is taught annually.
The course is taught: every week. - Teacher's information
- http://physics.muni.cz/biophys/vyuka.shtml
- Enrolment Statistics (recent)
- Permalink: https://is.muni.cz/course/sci/spring2024/F8390