C2705 Principles of Organic Chemistry - seminar

Faculty of Science
Spring 2025
Extent and Intensity
0/2/0. 2 credit(s) (plus extra credits for completion). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
Mgr. Jaromír Literák, Ph.D. (seminar tutor)
Mgr. Patrik Pospíšil (seminar tutor)
Guaranteed by
Mgr. Jaromír Literák, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Timetable
Mon 17. 2. to Sat 24. 5. Mon 17:00–18:50 A08/309
Prerequisites
NOW( C2700 Organic Chemistry Principles )
Basic knowledge and skills in the field of general and inorganic chemistry.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
After finishing the course, students will be able to actively work with formulas representing the constitution and structural arrangement of molecules of organic substances. Students will be able to identify the functional groups contained in the molecules and deduce from their presence what physical and chemical properties the given substance will have. Furthermore, students will be equipped with basic knowledge about reagents and conditions used for chemical transformations of functional groups. Students will be able to deduce the structure of the products of mentioned reactions and also will be able to describe these transformations using reaction mechanisms.
Learning outcomes
After finishing the course, students will be able to actively work with formulas representing the constitution and spatial arrangement of molecules of organic substances. Students will be able to identify the functional groups contained in the molecules and deduce from their presence what physical and chemical properties the given substance will have. Furthermore, students will be equipped with basic knowledge about reagents and conditions used for chemical transformations of functional groups. Students will be able to deduce the structure of the products of mentioned reactions and also will be able to describe these transformations using reaction mechanisms.
Syllabus
  • 1) Octet rule and formal charge, formation and cleavage of chemical bonds, bonding abilities of atoms, basic classification of organic reactions, writing mechanisms of organic reactions, oxidation state of atoms in organic molecules and redox reactions
  • 2) Hybridization and shape of organic molecules, induction effect, conjugation, resonance effect, resonance structures, hyperconjugation, stability of cations and anions
  • 3) Polarity and polarizability, acidity and basicity, nucleophilicity and electrophilicity
  • 4) Functional groups, rules of systematic nomenclature of organic compounds
  • 5) Isomerism, types of isomers, configuration and conformation, absolute configuration, CIP rules, different forms of representation of organic molecules - Fischer projection, Newman projection, Haworth projection, wedge and dash representation
  • 6) Nucleophilic substitution (bimolecular and monomolecular), elimination (bimolecular and monomolecular), influence of the character of the substrate and base during the elimination reaction (thermodynamic vs. kinetic product), competition of substitution and elimination (nucleophile vs. base)
  • 7) Electrophilic addition to alkenes, polyenes and alkynes – hydrohalogenation, halogenation, hydration, addition reactions on the double bond – hydrogenation, dihydroxylation, epoxidation, ozonolysis, HBr radical addition
  • 8) Aromatic compounds – Hückel's rule, aromatic electrophilic substitution, aromatic nucleophilic substitution, heterocycles
  • 9) Nucleophilic addition to carbonyl – formation of hydrate, acetal, imine, cyanohydrin, addition of organometallic reagents, hydride addition, conjugate addition to α,β-unsaturated carbonyl compounds (thermodynamic vs. kinetic product)
  • 10) Carboxylic acids and their derivatives - addition of a nucleophile to a carbonyl with a leaving group, enols and enolates - formation and reactions (alkylation, halogenation, aldol condensation)
  • 11) Ethers, alcohols and phenols - properties, preparation and reactivity, sulfides and thiols, amines - alkylation and reductive amination, nitro compounds, organometallic compounds
  • 12) Halogen derivatives, alkanes, radical reactions
Literature
    recommended literature
  • MCMURRY, John. Organická chemie. 1. vyd. Brno: VUTIUM, VŠCHT Praha, 2015, 1200 pp. ISBN 978-80-214-4769-1. info
  • CLAYDEN, Jonathan. Organic chemistry. 2nd ed. Oxford: Oxford University Press, 2012, xxv, 1234. ISBN 9780199270293. info
  • LITERÁK, Jaromír. Příklady ke Speciálnímu semináři z organické chemie I. Elportál. Brno: Masarykova univerzita, 2010. ISSN 1802-128X. URL info
Teaching methods
Seminar – practice of the subject matter discussed during the lectures, checking completed homework, writing interim tests
Assessment methods
Interim written tests on three predetermined dates and a final credit test. In order to pass the course successfully, students need to obtain an average of 50 % score from the partial tests during the semester and at least 60 % from the summary test at the end of the semester.
The second condition is active participation in seminars. Only one absence without giving a reason and a maximum of two additional absences justified by a proper excuse (e.g. for health reasons) is allowed.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2024.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/spring2025/C2705