E6080 Environmental Genomics

Faculty of Science
Spring 2025
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA (lecturer)
Mgr. Petra Brenerová, Ph.D. (lecturer)
doc. RNDr. Sabina Ševčíková, Ph.D. (lecturer)
Mgr. Albert Kšiňan, Ph.D. (lecturer)
Guaranteed by
doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA
RECETOX – Faculty of Science
Contact Person: doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA
Supplier department: RECETOX – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
This subject aims to get students acquainted with the scientific field of Environmental genomics, focusing on the interactions between humans and their environment on the genomic level (with so-called gene-environment interactions) and associated interactions between the host and his/her microbiota, epigenomics, gene expression, genetically conditioned susceptibility to complex diseases and PGx (pharmacogenetics and pharmacogenomics).
Learning outcomes
After taking the course, the student will be able to understand the concept of environmental genomics, PGx and population genetics, - to discuss the effects of exposure factors on the human genome and microbiome, - to explain the meaning of genetic predispositions to diseases, - to understand the methods of studying the genetic component in complex diseases, and - will get the basic knowledge of multi-omics approaches to the human health and disease.
Syllabus
  • 1. Introduction to human environmental genomics (definition of the areas of interest: gene-environment and gene-gene interactions, genetics of complex diseases, epigenomics). 2. Population genetics, genetic association studies, methods for the study of complex diseases. 3. Genetic predispositions (susceptibility) to complex diseases – case-control studies. 4. Genetic predisposition (susceptibility) to complex diseases – immunogenetics and oncogenetics. 5. PGx (pharmacogenetics and pharmacogenomics) – personalized medicine. 6. Human microbiome in health and disease, multi-omics approaches, metatranscriptome, metabolome and metaproteome, microbiome evolution. 7. Human microbiome and metabolization of xenobiotics, antibiotic resistance. 8. Human microbiome the gut-brain axis, neurodevelopment and neurodegeneration. 9. Human microbiome – oral microbiome, microbiome of the gastrointestinal tract, oncobiome. 10. Human microbiome and reproduction. 11. Human microbiome and epigenetic modifications. 12. Epigenetics in oncology.
Literature
  • https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/290458/sgenomics-e-e.pdf
  • https://doi.org/10.1093/hmg/ddh228
Teaching methods
The subject will be taught by means of lecturing with presentations.
Assessment methods
The lecture attendance is not compulsory; it is, however, strongly recommended for being able to understand the topics. Classification will be performed by the end of the term in the form of a written test (20 questions) with a subsequent face to face examination.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Spring 2022.
  • Enrolment Statistics (Spring 2025, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2025/E6080