aVLBE05 Essentials of Human Biochemistry

Lékařská fakulta
podzim 2024
Rozsah
2/0/0. 30. 3 kr. Ukončení: z.
Vyučující
doc. RNDr. Jiří Dostál, CSc. (přednášející)
MUDr. Michaela Králíková, Ph.D. (přednášející)
RNDr. Hana Paulová, CSc. (přednášející)
Mgr. Jiří Slanina, Ph.D. (přednášející)
prof. RNDr. Eva Táborská, CSc. (přednášející)
doc. RNDr. Josef Tomandl, Ph.D. (přednášející)
Mgr. Marie Tomandlová, Ph.D. (přednášející)
Iva Audy (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
St 16:00–17:40 A16/213
Předpoklady
aVLBC0321p Biochemistry I - lecture || aZLBC0321p Biochemisty I - lecture
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 44 stud.
Momentální stav registrace a zápisu: zapsáno: 24/44, pouze zareg.: 0/44
Mateřské obory/plány
Cíle předmětu
The aim is to understand the basic biochemical processes characteristic at the cell level and individual tissues and organs and the principles of their regulation.
Výstupy z učení
Upon completion of the course, the student will be able to:
- Demonstrate an understanding of bioenergetics and biological oxidation, including redox reactions and their role in cellular energy production.
- Apply knowledge of enzyme kinetics and factors influencing enzyme activity to analyze and interpret biochemical pathways.
- Describe principles of the regulation of gene expression and its significance in cellular function and disease.
- Understand the basic metabolism of carbohydrates and the implications of carbohydrate-related disorders like diabetes mellitus and explain the regulation of blood glucose levels.
- Comprehend the metabolism of lipids and the relevance of lipid-related disorders such as hyperlipidemia.
- Understand cholesterol metabolism, its role in cellular processes, and the synthesis of cholesterol and steroids.
- Understand amino acid metabolism, including the urea cycle, and recognize disorders related to amino acid metabolism.
- Comprehend the metabolism of nitrogen-containing compounds, such as nucleotides and heme, and understand purine and pyrimidine metabolism, disorders related to nitrogen metabolism.
- Understand the integration of carbohydrate, lipid, and protein metabolism in various physiological states.
- Understand the regulation of water balance, electrolyte concentrations, and acid-base balance, as well as the mechanisms involved in maintaining homeostasis.
- Describe cell signalling pathways and signal transduction mechanisms, including the role of receptors, second messengers, and intracellular signalling cascades in physiological processes and diseases.
- Explain the process of blood clotting and the functions of the extracellular matrix, including collagen synthesis and bone metabolism.
Osnova
  • Bioenergetics and biological oxidation. Enzyme kinetics
  • Nucleic acid metabolism, gene expression and regulation
  • Carbohydrate metabolism and glucose homeostasis
  • Lipid metabolism
  • Cholesterol and steroids
  • Protein and amino acid metabolism
  • Nitrogen-containing compounds
  • Integration of body fuel metabolism in various states
  • Water, electrolyte, and acid-base homeostasis
  • Signal transduction pathways, control of cell metabolism
  • Hemostasis. Extracellular matrix
  • ROPOT
Literatura
    povinná literatura
  • Seminar texts and lecture handouts from the courses Biochemistry I and II
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    doporučená literatura
  • LIEBERMAN, Michael a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
  • RONNER, Peter. Netter's Essential Biochemistry. Philadelphia: Elsevier, 2018, 482 s. ISBN 978-1-929007-63-9. info
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
Výukové metody
Problem-based learning of biochemistry, reflecting basic knowledge from previous courses of Biochemistry I and II.
The essential biochemical topics will be presented (lecture-like mode), followed by immediate discussions (seminar-like mode). Students will be encouraged to see biochemical processes and relations in a broader perspective.
Metody hodnocení
Credit. Conditions for giving the course-unit credit: attendance, four absences will be tolerated. ROPOT is not a prerequisite for credit.
Vyučovací jazyk
Angličtina
Předmět je zařazen také v obdobích podzim 2023.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/med/podzim2024/aVLBE05