aVLIM051p Immunology - lecture

Faculty of Medicine
autumn 2024
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
prof. MUDr. Jiří Litzman, CSc. (lecturer)
prof. MUDr. Jindřich Lokaj, CSc. (lecturer)
Guaranteed by
prof. MUDr. Jiří Litzman, CSc.
Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Contact Person: prof. MUDr. Jiří Litzman, CSc.
Supplier department: Department of Clinical Immunology and Allergology – Institutions shared with St. Anne's Faculty Hospital – Faculty of Medicine
Timetable
Wed 18. 9. 16:30–19:00 I.CHK N01001, Wed 25. 9. 16:30–19:00 I.CHK N01001, Wed 2. 10. 16:30–19:00 I.CHK N01001, Wed 9. 10. 16:30–19:00 I.CHK N01001, Wed 16. 10. 16:30–19:00 I.CHK N01001, Wed 23. 10. 16:30–19:00 I.CHK N01001, Wed 30. 10. 16:30–19:00 I.CHK N01001, Wed 6. 11. 16:30–19:00 I.CHK N01001, Wed 13. 11. 16:30–19:00 I.CHK N01001, Wed 20. 11. 16:30–19:00 I.CHK N01001, Wed 27. 11. 16:30–19:00 I.CHK N01001, Wed 4. 12. 16:30–19:00 I.CHK N01001, Wed 11. 12. 16:30–19:00 I.CHK N01001
Prerequisites (in Czech)
aVLBC0422p Biochemistry II - lecture && aVLFY0422p Physiology II - lecture
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course covers basic aspects of the structure and function of the immune system in humans. Topics include mechanisms of non-specific immunity with the main emphasis on the inflammatory process, such as humoral and cellular branches of the specific immune response. It includes mainly mechanisms of activation of the immune response and its regulation. Special emphasis is given to immune response to microbes and immunoprophylaxis to infectious and non-infectious diseases. After finishing the course the students will understand and be able to explain the mechanisms of the immune response in physiology, such as immune system disturbances leading to immunopathological diseases.
Learning outcomes
- The student will understand basic mechanisms of functioning of the immune system, functional characteristics of the specific and non-specific immune responses, and the interrelationship of these reactions;
- The student will understand the importance of the immune system in defence against microbes and tumour growth as well as the principles of active and passive artificial immunization;
- The student will become acquainted with the regional specificity of the individual compartments of the immune system;
- The student will be acquainted with the mechanisms of immune tolerance and the mechanisms of its breakdown leading to autoimmune diseases;
- The student will be familiar with the principles of immunological hypersensitivity and the consequences leading to the development of hypersensitivity reactions;
- The student will be acquainted with basic principles of pharmacological influence of immune reactivity;
- The student will be acquainted with the most important primary and secondary immunodeficient states;
Syllabus
  • Immunology in medicine. Medical subject allergology and clinical immunology. Physiology and pathology of the immune system.
  • Immunological concept of “own”, “foreign”, “dangerous”.
  • Anatomy and cellular elements of the immune system.
  • Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation.
  • B lymphocytes and immunoglobulins.Genetic basis of immunoglobulin heterogeneity.Biological properties of antibodies.
  • T-lymphocytes, their development and effector functions. Polarisation of T-lymphocytes (T1, T2, Th17). Cytotoxicity. Cytokines. Major histocompatibility complex: structure, function.
  • Activation of T and B cells by antigen.Interactions between antigen-presenting cells and T- and B-lymphocytes.
  • Regulation of the immune reaction.
  • Compartmentalization of the immune response. Mucosal immunity.
  • Immunity against infectious agents. Microbial antigens.
  • Active and passive immunisation.
  • Age factor and immune system in humans
Literature
    recommended literature
  • ABBAS, Abul K., Andrew H. LICHTMAN and Shiv PILLAI. Basic immunology : functions and disorders of the immune system. Fifth edition. St. Louis: Elsevier, 2016, x, 335. ISBN 9780323390828. info
Teaching methods
The subject is given in a form of lectures
Assessment methods
Oral exam
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2024/aVLIM051p