EMMO0411p Molecular Biology - Lecture

Faculty of Medicine
spring 2025
Extent and Intensity
3/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jan Šmarda, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jan Šmarda, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Prerequisites (in Czech)
EMBI0222p Biology II - lecture || EMBI0222s Biologie II - seminář
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Cíle předmětu anglicky The aim of the course is to explain the structure of genomes of various organisms, to provide students with information how genetic information is stored and expressed. Students are also familiarized with the processes by which genetic information can be changed and what this means for the phenotype of the cell/organism.
Learning outcomes
Students will be able to understand and explain basic principles of molecular biology and genetics on molecular level and their basic phenomena - the structure, replication, expression and changes of genes.
Syllabus
  • 1. History of molecular biology. Nucleic acids (primary, secondary and tertiary structure of DNA and RNA, different conformations of DNA and their significance in biological systems) • 2. Genetic information and the genetic code. • . 3. Molecular structure of procaryotic and eucaryotic genome. • 4. Replication of procaryotic and eucaryotic genome • 5. Transcription of prokaryotic and euckryotic genome. Posttranscriptional modification and processing of RNA, especially in eukaryotes. Mechanisms of splicing and self-splicing • 6. Translation of prokaryotic and eukaryotic mRNA. Posttranslational processing • 7. Regulation of gene expression in prokaryotes and eukaryotes • 8. Molecular basis of acquired immunity • 9. Molecular mechanisms of mutagenesis and recombination Molecular basis of cancerogenesis (oncogenes, antioncogenes. Repair mechanisms of damaged DNA • 10. Mobile genetic elements, Transposons and retrotransposons. • 11. Basic principles of gene engineering
Literature
    recommended literature
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Translated by Jiřina Relichová. Druhé, aktualizované vydá. Brno: Masarykova univerzita, 2017, xix, 844. ISBN 9788021086135. info
  • WILSON, John H. and Tim HUNT. Molecular biology of the cell : the problems book / John Wilson and Tim Hunt. Sixth edition. New York: Garland Science, 2014, xvi, 966. ISBN 9780815344537. info
  • CLARK, David P. Molecular biology. Amsterdam: Elsevier, 2005, xviii, 784. ISBN 0121755517. info
  • ALBERTS, Bruce. Essential cell biology. 2nd ed. New York: Garland Science, 2004, xxi, 740. ISBN 0815334818. info
    not specified
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Roman PANTŮČEK, Jana KAILEROVÁ, Jiřina RELICHOVÁ, Vladislava RŮŽIČKOVÁ, Jan ŠMARDA, Jan ŠMARDA and Jiří ŠTĚPÁN. TERMINOLOGIE MOLEKULÁRNÍ BIOLOGIE. České odborné termíny, definice a anglické ekvivalenty (Terminology of molecular biology). První vydání. Brno: Vydavatel Prof. RNDr. Stanislav Rosypal, DrSc. Vodova 80, 612 00 Brno, 2001, 300 pp. ISBN 80-902562-3-6. URL info
Teaching methods
Lectures are based on power-point pictures, tables and texts elaborated accordindg to textbooks, monographs and scientific papers which are explained and complemented with teacher comments. All the presentations are available on IS MUNI.
Assessment methods
Visiting of the course is not obligatory. The exam is a written test in which students should answer 50 questions covering main topics of individual lectures. To pass the exam the students should answer 60% of the answers.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught: every week.
Information on the extent and intensity of the course: 45.
The course is also listed under the following terms spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (spring 2025, recent)
  • Permalink: https://is.muni.cz/course/med/spring2025/EMMO0411p