LF:EMPF0521p Pathological Physiology I - le

EMPF0521p Pathological Physiology I - lecture

Faculty of Medicine
autumn 2024

Extent and Intensity

2/0/0. 1 credit(s). Type of Completion: z (credit).

Teacher(s)

prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
Bc. Lenka Hladíková (assistant)

Guaranteed by

prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine

Timetable

Thu 16:00–17:40 B11/334

Prerequisites

EMBC0422c Biochemistry II - practice && EMBC0422s Biochemistry II - seminar && EMBC0422p Biochemistry II - lecture && EMFY0422c Fyziologie II - cvičení && EMFY0422p Fyziologie II - přednáška
Aim of the subject is to teach the students basic principles of etiology and pathogenesis of diseases especially focused on embryological consequences

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

Specialist for Clinical Embryology and Assisted Reproduction Technology (programme LF, M-EZ)

Course objectives

Aim of the subject is to teach the students basic principles of etiology and pathogenesis of diseases especially focused on embryological consequences

Learning outcomes

Are taken from OPTIMED and expressed in questions to exam. General pathophysiology • Student characterizes state of healthy and disease • Student calls main sources of interindividual variability • Student discusses influences which determined population frequencies of alleles • Student distinguishes mutation types according to the mechanism • Student describes base principles of methods detecting human genome and its variability • Student summarises base types of DNA reparation • Student describes base characteristics of monogenic diseases • Student discusses base principles and indications of gene therapy • Student knows an importance of the term of pharmacogenetics • Student demonstrates understanding of an influence of external factors on disease development • Student characterizes base features of complex diseases • Student summarises importance of epigenetics • Student describes pathophysiology of stress reaction • Student defines homeostasis term • Student is able to describe base principles of multicellular organism functioning • Student identifies disorder of growth and development from ontogenetic point of view • Student describes results of hypoxia including HIF 1 program • Student explains a difference between local and systemic inflammation • Student explains pathogenesis of oedema • Student discusses etiopathogenesis of the most important ion homeostasis disturbances • Student distinguishes base acid base balance disturbances and possibilities of their compensation • Student applies knowledge of volume and tonicity regulation • Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy • Student knows principles and performance of base coagulation tests • Student explains wound healing process with examples of pathological healing • Student knows pathophysiology of urgent states in oncology diseases • Student explains an importance of micronutrients abnormalities • Student knows results of abnormal vitamin levels • Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins • Student discusses pathophysiology of protein metabolism • Student understands the base principles of regulation of glucose • Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders • Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes • Student describes onset, signs and results of heart and vessels remodelling • Student applies chronobiology knowledge for explication of different pathophysiological changes

Syllabus

Pathophysiology: an integrating medical speciality. Aetiology and pathogenesis of diseases. Ethics of experiments in medicine. • Atherosclerosis. Remodelling of blood vessels. Diseases of peripheral blood vessels. • Pressure and volume overload of heart. Sytolic and diastolic heart dysfunction. Heart remodelling. Heart failure. • Metabolism of myocardium, ischemic heart disease, myocardium infarction. • Pathophysiology of liver disorders. • Pathophysiology of gas exchange and ventilation control in the lungs. • Lung diseases. • Inflammation. Acute phase reaction. Systemic reaction of organism on damage. Regeneration and reparation. Wound healing. Pathophysiology of blood clotting. • Acid base balance disorders. • Pathophysiological aspects of renal functions. Kidney diseases. Acute and chronic renal failure. • Pathophysiology of water and electrolytes. Tonicity and volume disturbances. • Bone and muscles disordes.

Literature

required literature

PÁVKOVÁ GOLDBERGOVÁ, Monika, Kamil ĎURIŠ, Jaromír GUMULEC, Jaromír GUMULEC, Adam PAŽOUREK and Anna VAŠKŮ. Patofyziologie v obrazech (Pathophysiology in Pictures). 1. dotisk 1. vyd. Brno: Masarykova univerzita, 2018. ISBN 978-80-210-8323-3. info
SILBERNAGL, Stefan and Florian LANG. Atlas patofyziologie. Translated by Miloš Langmeier. 2., české vyd. Praha: Grada, 2012, x, 406. ISBN 9788024735559. info
NEČAS, Emanuel. Obecná patologická fyziologie. 3. vyd. Praha: Karolinum, 2009, 377 s. ISBN 9788024616889. info

Teaching methods

Lessons are led in the form of lectures.

Assessment methods

The attendance of lectures and only one absence on practicals per semester are necessary for succesfull accomplishment of the subject. Continous control of knowledge in practicals is fully in powers of teachers (assays, tests...). Elaborated proceedings of practicals will be put to teachers for credit.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
Information on the extent and intensity of the course: 30.

Teacher's information

http://www.med.muni.cz/fyziol
Patologická fyziologie - přednášky

Podzimní semestr 2024 – Embryolog, Zubní lékařství B11/334

čtvrtek 16:00 – 17:40

19. 9. Zdraví a nemoc-obecné příčiny nemocí-etiologie a patogeneze – syndrom/symptom. Zevní faktory vzniku nemocí – fyzikální, chemické a biologické patogenní faktory. Genetická predispozice nemocí. Epigenetická modulace genomu pod vlivem faktorů prostředí.