EMPF0622p Pathological Physiology II - lecture

Faculty of Medicine
spring 2025
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
Bc. Lenka Hladíková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to train students in dynamic thinking about etiology and pathogenesis of diseases focused on special pathophysiology as well as molecular pathophysiology themes: • Pathophysiology of cardiovascular system. • Pathophysiology of digestive system, nutrition deficits. • Pathophysiology of endocrine system, metabolic diseases. • Pathophysiology of hemopoietic system, neoplasias. • Rheumatic diseases. Immunologically conditioned diseases. • Pathophysiology of respiratory tract. • Pathophysiology of kidneys, disturbances in metabolism of water and ions. • Pathophysiology of nervous system. • Pathophysiology of muscles and sensory organs.
Learning outcomes
Student discusses the etiopathogenesis of atherosclerosis at the molecular, cellular and tissue level • Student will describe the etiopathogenesis of systolic and diastolic dysfunction of myocardium and pressure and volume overload of the heart • Student distinguishes between the causes of arrhythmias • Student categorizes the clinical forms of ischemic heart disease and clinically important consequences of heart failure syndrome • Student will explain the general and special pathophysiology of shock conditions and basic types of shock • Student will sum up the most common causes of disorders of the respiratory apparatus • Student characterizes the pathophysiology of chronic bronchitis and pulmonary emphysema • Student will sum up the pathogenesis of respiratory insufficiency • Student controls the issue of regulation of renal perfusion • Student can explain the issue glomerulopathy • Student categorizes causes of acute and chronic renal failure • Student will explain the difference between acute and chronic effects of hormones • Student categorizes acute and chronic renal failure • Student will explain the difference between acute and chronic effects of hormones • Student discusses the pathophysiology of clinically significant endocrine disruption of the function • Student will describe the pathophysiology of clinically significant gastrointestinal disorders, from a clinical point of view • Student will describe the anemic syndrome including the effects of anemic hypoxia • Student discusses different classification of anemias • Student discusses the pathophysiological aspects of transfusion of blood and blood derivatives, • Student will describe the main categories of diseases of white blood cells • Student distinguishes principled differences between physiological and pathological blood clotting • Student discusses the most important hypocoagulation and hypercoagulation disorders • Student will sum up the etiopathogenesis of common diseases of the joints, • Student demonstrates a knowledge of the etiopathogenesis of diseases of the muscle and neuromuscular plate • Student rattles off examples of failures of a sensory sensation • Student demonstrates examples of common neurodegenerative diseases of CNS • Student discusses the pathophysiology of epilepsy, • Student will use knowledge of the composition of cerebrospinal fluid • Student argues the importance of stability of intracranial pressure and its components for the creation of intracranial hypertension • Student will sum up the function of autonomous (vegetative) system • Student will sum up the function of movement system and consequences of its failure • Student describes the systems important for the existence of consciousness and waking
Syllabus
  • DNA diagnostics in complex diseases. Pharmacogenetics and gene therapy • General pathophysiology of endocrine system • Special pathophysiology of endocrine system • Pathophysiology of fetoplacental unit • Pathophysiology of food intake disorders • Pathophysiology of gastrointestinal disorders • Pathophysiology of bones and muscles • Pathophysiology of chosen allergic and autoimmune disorders • Pathophysiology of hematopoiesis and blood clotting • Pathophysiological aspects of protein metabolism • Pathophysiological aspects of lipid metabolism • Pathophysiological aspects of sugars metabolism • Pathophysiology of motoric system • Neurodegenerative disorders • Pathophysiology of urgent events in oncology diseases
Literature
    required literature
  • PÁVKOVÁ GOLDBERGOVÁ, Monika, Kamil ĎURIŠ, Jaromír GUMULEC, Jaromír GUMULEC, Adam PAŽOUREK and Anna VAŠKŮ. Patofyziologie v obrazech (Pathophysiology in Pictures). 1. dotisk 1. vyd. Brno: Masarykova univerzita, 2018. ISBN 978-80-210-8323-3. info
  • DAMJANOV, Ivan. Pathophysiology. Illustrated by Matthew Chansky. 1st ed. Philadelphia: Saunders/Elsevier, 2009, vii, 464. ISBN 9781416002291. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 4. dotisk 1. vyd. Praha: Karolinum, 2007, s. 381-760. ISBN 9788024606743. info
Teaching methods
lecture
Assessment methods
Oral exam. The final exam is oral; student will answer 4 questions selected by lot from general, special pathophysiology, practicals and lectures. Individual evaluation from practicals (described by assistant) is taken into account.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught: every week.
Information on the extent and intensity of the course: 30.
Teacher's information
http://www.med.muni.cz/fyziol
The course is also listed under the following terms spring 2023, spring 2024.
  • Enrolment Statistics (spring 2025, recent)
  • Permalink: https://is.muni.cz/course/med/spring2025/EMPF0622p