EMVB0511p Basics of Developmental Biology

Faculty of Medicine
autumn 2024

The course is not taught in autumn 2024

Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Tomáš Bárta, Ph.D. (lecturer)
prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
prof. RNDr. Marcela Buchtová, Ph.D. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
Guaranteed by
prof. RNDr. Marcela Buchtová, Ph.D.
Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine (50,00 %), Section of Animal Physiology and Immunology – Department of Experimental Biology – Biology Section – Faculty of Science (50,00 %)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to acquaint students with the molecular and mechanistic principles of controlling the development of an organism and maintaining its histomorphological features throughout individual´s lifespan.
Learning outcomes
After completing the course, the student will:
- understand the general principles of intracellular and extracellular signalling, which are applied in the development of the organism and during its entire life.
This information will, among other things, allow the student to understand the development of developmental abnormalities and some diseases.
Syllabus
  • 1) Principles of signaling during embryogenesis: intercellular communication
  • 2) Role of homeobox genes in embryonic development
  • 3) Key signaling pathways in development and their role: SHH
  • 4) Key signaling pathways in development and their role: FGF
  • 5) Key signaling pathways in development and their role: WNT
  • 6) Key signaling pathways in development and their role: TGF
  • 7) Key signaling pathways in development and their role: Notch
  • 8) Other signalling pathways and their mutual interactions in development
  • 9) Regulation of cell migration and EMT in embryogenesis
  • 10) The role of cell adhesions in morphogenesis
  • 11) Regulation of cell differentiation and preservation of their differentiation status
  • 12) The role of apoptosis in morphogenesis
  • 13) The role of senescence in development
Literature
    recommended literature
  • GILBERT, Scott F. Developmental biology. Tenth edition. Sunderland, MA USA: Sinauer Associates, Inc., 2014, xx, 719. ISBN 9780878939787. info
    not specified
  • Lewis Wolpert and Cheryll Tickle, Principles of Development, 4th Edition, ISBN-13: 978-0199554287.
Teaching methods
Lecture
Assessment methods
A written test exam, accompanied by a discussion on the selected topic from the test.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught every week.
Information on the extent and intensity of the course: 30.
  • Permalink: https://is.muni.cz/course/med/autumn2024/EMVB0511p