VLBC0422s Biochemistry II - seminar

Faculty of Medicine
spring 2025
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
Mgr. Jana Gregorová, Ph.D. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
doc. Mgr. Ondřej Peš, Ph.D. (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
Mgr. Jindra Smutná, Ph.D. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Marie Tomandlová, Ph.D. (seminar tutor)
Mgr. David Galuška (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: RNDr. Hana Paulová, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
VLBC0321s Biochemistry I - seminar && VLFY0321c Physiology I - practice && VLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to Biochemistry II - lecture. The aim of the course is to practise (i) the basic principles of intermediary metabolism and its regulation in various states of the organism at all levels, (ii) the characteristic features of metabolism of individual organs and tissues, (iii) the principles of maintaining homeostasis of the organism, including acid-base balance.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry. Analysers, POCT.
  • Blood glucose. Protein metabolism. Proteins in nutrition. Transport forms of ammonia.
  • Lipoproteins and their metabolism. Cholesterol transport and balance.
  • Relationships between major metabolic pathways of essential nutrients in various states. Malnutrition. Obesity. Metabolic syndrome. Metabolism during stress.
  • Liver functions, role in nutrient metabolism. Heme catabolism, hyperbilirubinemia. Role of liver in metabolism of hormones and vitamins. Metabolism of Fe.
  • Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volemia.
  • Acid-base balance, parameters, regulation, disorders. Buffer bases. Transport of O2 a CO2.
  • Major functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • Neurotransmitters and hormone receptors. The most common signal pathways.
  • Steroid and thyroid hormones.
  • Biochemistry of muscle work. Effect of NO. Energetics of muscle work.
  • Metabolism of Ca, Mg, P, F, I.
  • Extracellular matrix. Metabolism of connective tissue and skin, bone biomarkers.
Literature
    required literature
  • Studijní podklady a materiály k předmětu dostupné v IS MU.
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
    recommended literature
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
  • Doporučovaná literatura z lékařské fyziologie v předmětu VLFY0422p
Teaching methods
Seminary course. Class discussions on assigned topics.
Assessment methods
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Failure to meet the requirements of in-term tests requires a resit test, which may be repeated only once.
Detailed conditions are published in Study materials posted under the course/Interactive Syllabus.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
General note: Úspěšné ukončení předmětu je podmínkou přístupu ke zkoušce v předmětu VLBC0422p.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
Teacher's information
Information to seminars, the conditions for giving the course-unit credit and the syllabus are available in the IS MU in the Course-related instructions.
Consultations are possible after a personal arrangement with the teacher.
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (spring 2025, recent)
  • Permalink: https://is.muni.cz/course/med/spring2025/VLBC0422s