aZLHE0221p Histology and Embryology I - lecture

Faculty of Medicine
Spring 2018
Extent and Intensity
1/0/0. 0 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. MUDr. RNDr. Svatopluk Čech, DrSc. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
doc. MUDr. Miroslava Sedláčková, CSc. (lecturer)
MUDr. Irena Lauschová, Ph.D. (lecturer)
doc. RNDr. Petr Vaňhara, Ph.D. (lecturer)
MUDr. Ivana Baltasová (assistant)
MUDr. Jana Dumková, Ph.D. (assistant)
Mgr. Hana Kotasová, Ph.D. (assistant)
MUDr. Eva Mecová (assistant)
Guaranteed by
doc. MVDr. Aleš Hampl, CSc.
Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Histology and Embryology – Theoretical Departments – Faculty of Medicine
Timetable
Thu 8:30–9:20 F01B1/126
Prerequisites (in Czech)
( aZLAN0131s Anatomy I - seminar || ZLAN0131s Anatomy I - seminar ) && ( aZC011 Handling chemical substances || ZC011 Handling chemical substances )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Main objective of the subject is to combine programmed teaching of histology ana embryology that occupy a key position among subjects of the theoretical study on medical faculties. At the end of the course students should be able to: - in histology a) define basic terms and categories of the subject and apply used classification system in the praxis; b) describe and explain structure and function of animal cells on submicroscopic and molecular levels; c) describe and explain structural characteristics of epithels, connective and supporting tissues (incl. their function), muscle tissue including mechanism of muscle contraction and nerve tissue; d) identify basic tissues and main organs of the human body in histological slides; e) analyze the microscopic structure of organs under normal conditions and compare it with changes evoked with pathological changes or alterations; f) understand existing close interrelations between structure and function of individual tissues and organs of the human body; - in embryology: 1) explain the development of gametes, meiosis principle and regulation processes during gametogenesis; 2) discuss main developmental processes and genetic controle of development; 3) describe early development of the human embryo incl. development of extraembryonic structures; 4) categorize phases of prenatal development and characterize key developmental stages of individual organ systems.
Learning outcomes
At the end of the course students should be able to:
- in histology
a) define basic terms and categories of the subject and apply used classification system in the praxis;
b) describe and explain structure and function of animal cells on submicroscopic and molecular levels;
c) describe and explain structural characteristics of epithels, connective and supporting tissues (incl. their function), muscle tissue including mechanism of muscle contraction and nerve tissue;
d) identify basic tissues and main organs of the human body in histological slides;
e) analyze the microscopic structure of organs under normal conditions and compare it with changes evoked with pathological changes or alterations;
f) understand existing close interrelations between structure and function of individual tissues and organs of the human body;
- in embryology:
1) explain the development of gametes, meiosis principle and regulation processes during gametogenesis;
2) discuss main developmental processes and genetic controle of development;
3) describe early development of the human embryo incl. development of extraembryonic structures;
4) categorize phases of prenatal development and characterize key developmental stages of individual organ systems.
Syllabus
  • 1. Introduction. The object and significance of histology. Relevance of histology to other biomedical disciplines. History, current state, and future of histology. Methodologies to study a structure of cells and tissues. Cytology: The cell - definition, characteristics, compartmentalization. Cell nucleus - ultrastructure and function, chromosomes, nucleolus.Introduction
  • 2. Organelles - structure, localization, and function. Cell inclusions and pigments. Cytoskeleton - microfilaments, intermediate filaments and microtubules. Cell surface structures and intercellular bonds. Cell division cycle. Cell differentiation, cell migration, organization of cells into tissues and organs - general aspects.
  • 3. General embryology. Definition. The object and significance of embryology. Overview of the early human development: The phases of the human ontogeny. Human gametes - their structure, physiology and origin (gametogenesis). Differences between spermatogenesis and oogenesis. Transport of gametes. Sperm capacitation. Fertilization and cleavage. Activation of the embryonal genome. Nuclear transfer. Morula and blastocyst. Embryonic stem cells. Outline of the implantation. Abnormal sites of implantation (extrauterine pregnancies).
  • 4. The development of the germ disc: origin of the intraembryonic mesoderm and notogenesis (development of the chorda dorsalis). Somites and their derivatives. Outline of the development of fetal membranes: amniotic sac, chorion, and placenta. Function of the placenta. The umbilical cord. Anomalies of the placenta and umbilical cord. Development of external shape of the embryo and fetus. The rule of Hasse. Uterine growth during pregnancy. Parturition. Marks of the mature and full-term fetus. Position, posture and presentation of the fetus. Multiple pregnancy: mono- and dizygotic twins; arrangement of fetal membranes in twins.
  • 5. General histology. Tissues - definition, their origin, and classification. Connective and supporting tissue - general characteristics, their components and classification. The connective tissue proper - types, main distribution, and function.
  • 6. Supporting tissues - cartilage and bone - types, main distribution, and function. Histogenesis and regeneration of connective tissues.
  • 7. Epithelial tissue - definition, classification, and histogenesis. Epithelial membranes and glandular epithelium - an overview. Characteristics of glandular cells. Absorptive, respiratory, and sensory epithelia.
  • 8. Neural tissue - general characteristics and classification. Neurons – structure and function. Synapse. Neuroglial cells - types and function. Sheaths of nerve fibres. Conduction of nerve impulses. Histogenesis and regeneration of the neural tissue.
  • 9. Muscle tissue - general characteristics and classification. Smooth muscle tissue. Skeletal muscle tissue. Ultrastructure of the myofibrils. Mechanism of the muscle contraction. Cardiac muscle tissue. Inervation and vascularization of the muscle. Muscle histogenesis and regeneration.
  • 10. Blood cell morphology: Erythrocytes, leukocytes and thrombocytes. Differential white cell count. Prenatal and postnatal hematopoiesis. Erythropoiesis, granulopoiesis, thrombopoiesis.
  • 11. Microscopic anatomy and special embryology. Cardiovascular system. Microscopic structure of the heart, excitomotoric system - its structural peculiarities. Blood vessels - arteries and veins - structural differences. Capillary bed. Lymph vessels and capillaries.
  • 12. Development of the heart. Primitive blood circulation in the embryo. Fetal blood circulation.
Literature
    recommended literature
  • MESCHER, Anthony L. Junqueira's basic histology : text and atlas. 13th ed. New York: McGraw-Hill Medical, 2013, xi, 544. ISBN 9781259072321. info
  • MOORE, Keith L., T. V. N. PERSAUD and Mark G. TORCHIA. Before we are born : essentials of embryology and birth defects. 8th ed. Philadelphia, PA: Elsevier Saunders, 2013, xviii, 348. ISBN 9781437720013. info
    not specified
  • LOWE, James S. and Peter G. ANDERSON. Stevens and Lowe´s Human Histology. 4th. Elsevier, 2015. ISBN 978-0-7234-3502-0. info
  • OVALLE, William K., Patrick C. NAHIRNEY and Frank H. NETTER. Netter's essential histology. 2nd ed. Philadelphia, PA: Elsevier/Saunders, 2013, xv, 517. ISBN 9781455706310. info
  • MOORE, Keith L., T. V. N. PERSAUD and Mark G. TORCHIA. The developing human : clinically oriented embryology. 9th ed. Philadelphia, PA: Saunders/Elsevier, 2013, xix, 540. ISBN 9781437720020. info
  • SADLER, T. W. Langman's medical embryology. 12th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012, xiii, 384. ISBN 9781451144611. info
Teaching methods
lectures
Assessment methods
Students will pass examination after completing Histology and embryology II - lecture. All informations about required knowledge and the course of examination are on web site: http://www.med.muni.cz/histology/education
Language of instruction
English
Further Comments
Study Materials
The course is taught annually.
Teacher's information
http://www.med.muni.cz/histology/education
The course is also listed under the following terms Spring 2016, Spring 2017, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (Spring 2018, recent)
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